methyl 1-acetyl-4-(4-but-2-ynyloxybenzene-sulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate

Base Information

Chemical Name:methyl 1-acetyl-4-(4-but-2-ynyloxybenzene-sulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate
CAS No.:287121-21-5
Molecular Formula:C₂₃H₂₄N₂O₆S
Molecular Weight:456.519
Hs Code.:

Synonyms:methyl 1-acetyl-4-(4-but-2-ynyloxybenzene-sulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate

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Chemical Property of methyl 1-acetyl-4-(4-but-2-ynyloxybenzene-sulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate

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Technology Process of methyl 1-acetyl-4-(4-but-2-ynyloxybenzene-sulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate

There total 6 articles about methyl 1-acetyl-4-(4-but-2-ynyloxybenzene-sulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 764-01-2
methyl propargyl alcohol

: 233755-42-5
methyl 1-Acetyl-4-(4-hydroxybenzenesulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate

: 287121-21-5
methyl 1-acetyl-4-(4-but-2-ynyloxybenzene-sulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;
DOI:10.1016/S0960-894X(02)00633-9

Reference yield:

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 287121-21-5
methyl 1-acetyl-4-(4-but-2-ynyloxybenzene-sulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂

2: NaH / dimethylformamide

3: ammonium formate / 10 percent Pd/C / ethanol

4: Et₃N / CH₂Cl₂

5: sodium bicarbonate / methanol

6: BBr₃

7: DEAD; PPh₃ / tetrahydrofuran; toluene

With ammonium formate; boron tribromide; sodium hydride; sodium hydrogencarbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 5: Michael addition;
DOI:10.1016/S0960-894X(02)00633-9

Reference yield:

: 85622-74-8
methyl 3-hydroxy-2-(4-methoxybenzenesulfonylamino)propionate

: 287121-21-5
methyl 1-acetyl-4-(4-but-2-ynyloxybenzene-sulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / dimethylformamide

2: ammonium formate / 10 percent Pd/C / ethanol

3: Et₃N / CH₂Cl₂

4: sodium bicarbonate / methanol

5: BBr₃

6: DEAD; PPh₃ / tetrahydrofuran; toluene

With ammonium formate; boron tribromide; sodium hydride; sodium hydrogencarbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4: Michael addition;
DOI:10.1016/S0960-894X(02)00633-9