isogentisin

Base Information

• Chemical Name: isogentisin
• CAS No.: 491-64-5
• Molecular Formula: C14H10O5
• Molecular Weight: 258.2262
• Hs Code.: 2932999099
• Mol file: 491-64-5.mol

Synonyms:1,3-dihydroxy-7-methoxyxanthen-9-one;Isogentisin;1,3-dihydroxy-7-methoxyxanthone;1,3-Dihydroxy-7-methoxyxanthon,Isogentisin;1,3-Dihydroxy-7-methoxy-xanthen-9-on;1,3-Dihydroxy-7-methoxy-9H-xanthen-9-one;Xanthen-9-one,1,3-dihydroxy-7-methoxy;1,3-dihydroxy-7-methoxy-xanthen-9-one;1,3-Dihydroxy-7-methoxyxanthon;

Chemical Property of isogentisin

Chemical Property:

• Vapor Pressure: 2.09E-11mmHg at 25°C
• Melting Point: 241 °C
• Boiling Point: 519.4°Cat760mmHg
• PKA: 6.92±0.20(Predicted)
• Flash Point: 205°C
• PSA: 79.90000
• Density: 1.48g/cm³
• LogP: 2.36600

Purity/Quality:

98%min ^*data from raw suppliers

Isogentisin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isogentisin

There total 3 articles about isogentisin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.2%

→ isogentisine (491-64-5)

Guidance literature:

With zinc(II) chloride; trichlorophosphate; at 85 ℃; for 3h;

Reference yield: 76.2%

3,5-dihydroxyphenol (108-73-6) + 5-methoxysalicylic acid (2612-02-4) → isogentisine (491-64-5)

Guidance literature:

With zinc(II) chloride; trichlorophosphate; at 75 ℃; Microwave irradiation;

DOI:10.1016/j.ejmech.2018.03.072

Reference yield:

→ isogentisine (491-64-5)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

3,5-dihydroxyphenol

5-methoxysalicylic acid

Downstream raw materials:

gentitein

1,3,7-Trimethoxyxanthon

1-hydroxy-3,7-dimethoxyxanthone

Refernces

• 1、 -. "Donor compound as Xanthone-NO well as preparation method and application thereof in preparation of anti-tumor drugs (by machine translation)". Page/Page column 5; 6; 8; 9. . Retrieved 2020/01/04.
• 2、 Wang, Penghui,Jiang, Lulu,Cao, Yang,Ye, Deyong,Zhou, Lu. "The design and synthesis of n-xanthone benzenesulfonamides as novel phosphoglycerate mutase 1 (PGAM1) inhibitors". . . Retrieved 2018/06/15.