5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one methanesulfonic acid salt

Base Information

Chemical Name:5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one methanesulfonic acid salt
CAS No.:1339944-34-1
Molecular Formula:CH₄O₃S*C₁₇H₁₈ClFN₂O₄S
Molecular Weight:496.965
Hs Code.:

Synonyms:5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one methanesulfonic acid salt

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Chemical Property of 5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one methanesulfonic acid salt

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Technology Process of 5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one methanesulfonic acid salt

There total 4 articles about 5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one methanesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1339944-34-1
5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one methanesulfonic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / N,N-dimethyl-formamide / 0.67 h

1.2: 0 - 60 °C

2.1: pyridine / 80 °C

3.1: 1-methyl-pyrrolidin-2-one / 12 h / 80 °C / Inert atmosphere

4.1: acetonitrile / 2 h / 50 °C

With triphenylphosphine; In pyridine; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 103766-25-2
5-chloro-4-hydroxy-2(1H)-pyridinone

: 1339944-34-1
5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one methanesulfonic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / N,N-dimethyl-formamide / 0.67 h

1.2: 0 - 60 °C

2.1: pyridine / 80 °C

3.1: 1-methyl-pyrrolidin-2-one / 12 h / 80 °C / Inert atmosphere

4.1: acetonitrile / 2 h / 50 °C

With triphenylphosphine; In pyridine; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1339944-36-3
tert-butyl 4-((5-chloro-2-oxo-1,2-dihydropyridin-4-yl)oxy)-piperidine-1-carboxylate

: 1339944-34-1
5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one methanesulfonic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 80 °C

2: 1-methyl-pyrrolidin-2-one / 12 h / 80 °C / Inert atmosphere

3: acetonitrile / 2 h / 50 °C

In pyridine; 1-methyl-pyrrolidin-2-one; acetonitrile;