N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(dimethylamino)propanamide

Base Information

Chemical Name:N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(dimethylamino)propanamide
CAS No.:1233953-81-5
Molecular Formula:C₂₉H₂₉ClN₆O₃
Molecular Weight:545.041
Hs Code.:

Synonyms:N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(dimethylamino)propanamide

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Chemical Property of N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(dimethylamino)propanamide

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Technology Process of N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(dimethylamino)propanamide

There total 13 articles about N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(dimethylamino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1233953-82-6
3-chloro-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

: 124-40-3
dimethyl amine

: 1233953-81-5
N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(dimethylamino)propanamide

Guidance literature:: 3-chloro-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide; dimethyl amine; With potassium iodide; In ethanol; Reflux;

With potassium hydroxide; In ethanol; at 0 ℃;
DOI:10.1021/jm201507x

Reference yield:

: 848133-76-6
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

: 1233953-81-5
N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(dimethylamino)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine hydrochloride / isopropyl alcohol / Reflux

2.1: hydrogenchloride / water / 5 h / Reflux

3.1: 50 °C

4.1: potassium iodide / ethanol / Reflux

4.2: 0 °C

With hydrogenchloride; pyridine hydrochloride; potassium iodide; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm201507x

Reference yield:

: 3964-52-1
2-chloro 4-aminophenol

: 1233953-81-5
N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(dimethylamino)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzaldehyde / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 24 h / 50 °C

2.1: pyridine hydrochloride / isopropyl alcohol / Reflux

3.1: hydrogenchloride / water / 5 h / Reflux

4.1: 50 °C

5.1: potassium iodide / ethanol / Reflux

5.2: 0 °C

With hydrogenchloride; pyridine hydrochloride; benzaldehyde; potassium iodide; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm201507x