Technology Process of L-Glutamine, N-(2-oxo-3-piperidinyl)-N2-(1-oxopropyl)-, ethyl ester, ( S)-
There total 10 articles about L-Glutamine, N-(2-oxo-3-piperidinyl)-N2-(1-oxopropyl)-, ethyl ester, ( S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; isobutyl chloroformate;
In
N,N-dimethyl-formamide;
at -10 ℃;
for 0.0833333h;
- Guidance literature:
-
With
dmap; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 2h;
under 760.051 Torr;
DOI:10.3762/bjoc.13.27
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 71 percent / NaHCO3 / dioxane; H2O / 2 h / Ambient temperature
2: 85 percent / dicyclohexylcarboimide, 4-(dimethylamino)pyridine / CH2Cl2 / Ambient temperature
3: 90 percent / ammonium formate / 10 percent Pd/C / methanol / 0.25 h / Ambient temperature
4: 75 percent / N-methylmorpholine, isobutyl chloroformate / dimethylformamide / 0.08 h / -10 °C
With
4-methyl-morpholine; dmap; ammonium formate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; isobutyl chloroformate;
palladium on activated charcoal;
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
