N₂,N₂,7-trimethyl-N₄-[(1S)-1-(4-nitrophenyl)ethyl]quinazoline-2,4-diamine

Base Information

• Chemical Name: N₂,N₂,7-trimethyl-N₄-[(1S)-1-(4-nitrophenyl)ethyl]quinazoline-2,4-diamine
• CAS No.: 1039736-59-8
• Molecular Formula: C₁₉H₂₁N₅O₂
• Molecular Weight: 351.408

Synonyms:N₂,N₂,7-trimethyl-N₄-[(1S)-1-(4-nitrophenyl)ethyl]quinazoline-2,4-diamine

Chemical Property of N₂,N₂,7-trimethyl-N₄-[(1S)-1-(4-nitrophenyl)ethyl]quinazoline-2,4-diamine

Chemical Property:

Purity/Quality:

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Technology Process of N₂,N₂,7-trimethyl-N₄-[(1S)-1-(4-nitrophenyl)ethyl]quinazoline-2,4-diamine

There total 3 articles about N₂,N₂,7-trimethyl-N₄-[(1S)-1-(4-nitrophenyl)ethyl]quinazoline-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-chloro-7-methyl-N-[(1S)-1-(4-nitrophenyl)ethyl]quinazolin-4-amine (1039736-58-7) + N,N-dimethylammonium chloride (506-59-2) → N2,N2,7-trimethyl-N4-[(1S)-1-(4-nitrophenyl)ethyl]quinazoline-2,4-diamine (1039736-59-8)

Guidance literature:

In tetrahydrofuran; isopropyl alcohol; Heating / reflux;

Reference yield:

7-methyl-2,4-dichloroquinazoline (25171-19-1) → N2,N2,7-trimethyl-N4-[(1S)-1-(4-nitrophenyl)ethyl]quinazoline-2,4-diamine (1039736-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: tetrahydrofuran; isopropyl alcohol / Heating / reflux

With triethylamine; In tetrahydrofuran; isopropyl alcohol;

Reference yield:

(S)-1-(p-nitrophenyl)ethylamine (4187-53-5,22038-87-5,42142-15-4,73069-55-3) → N2,N2,7-trimethyl-N4-[(1S)-1-(4-nitrophenyl)ethyl]quinazoline-2,4-diamine (1039736-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: tetrahydrofuran; isopropyl alcohol / Heating / reflux

With triethylamine; In tetrahydrofuran; isopropyl alcohol;

upstream raw materials:

2-chloro-7-methyl-N-[(1S)-1-(4-nitrophenyl)ethyl]quinazolin-4-amine

N,N-dimethylammonium chloride

7-methyl-2,4-dichloroquinazoline

(S)-1-(p-nitrophenyl)ethylamine

Downstream raw materials:

N₄-[(1S)-1-(4-aminophenyl)ethyl]-N₂,N₂,7-trimethylquinazoline-2,4-diamine

N-[4-((1S)-1-{[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}ethyl)phenyl]piperidine-4-carboxamide

tert-butyl 4-({[4-((1S)-1-{[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}ethyl)phenyl]amino}carbonyl)piperidine-1-carboxylate

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