8-chloro-6-(4-chlorophenyl)-N-methyl-4H-imidazo[1,5-a]-[1,4]benzodiazepine-3-carboxamide

Base Information

Chemical Name:8-chloro-6-(4-chlorophenyl)-N-methyl-4H-imidazo[1,5-a]-[1,4]benzodiazepine-3-carboxamide
CAS No.:1318262-18-8
Molecular Formula:C₁₉H₁₄Cl₂N₄O
Molecular Weight:385.252
Hs Code.:

Synonyms:8-chloro-6-(4-chlorophenyl)-N-methyl-4H-imidazo[1,5-a]-[1,4]benzodiazepine-3-carboxamide

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Chemical Property of 8-chloro-6-(4-chlorophenyl)-N-methyl-4H-imidazo[1,5-a]-[1,4]benzodiazepine-3-carboxamide

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Technology Process of 8-chloro-6-(4-chlorophenyl)-N-methyl-4H-imidazo[1,5-a]-[1,4]benzodiazepine-3-carboxamide

There total 3 articles about 8-chloro-6-(4-chlorophenyl)-N-methyl-4H-imidazo[1,5-a]-[1,4]benzodiazepine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1318262-32-6
8-chloro-6-(4-chlorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

: 74-89-5
methylamine

: 1318262-18-8
8-chloro-6-(4-chlorophenyl)-N-methyl-4H-imidazo[1,5-a]-[1,4]benzodiazepine-3-carboxamide

Guidance literature:: 8-chloro-6-(4-chlorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid; With isobutyl chloroformate; In chloroform; at 15 ℃; for 1h;

methylamine; In chloroform; at 15 ℃; for 0.5h;
DOI:10.1021/jm2001597

Reference yield:

: 1318262-10-0
ethyl 8-chloro-6-(4-chlorophenyl)-4H-imidazo[1,5-a]-[1,4]benzodiazepine-3-carboxylate

: 1318262-18-8
8-chloro-6-(4-chlorophenyl)-N-methyl-4H-imidazo[1,5-a]-[1,4]benzodiazepine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 0.5 h / Reflux

2.1: isobutyl chloroformate / chloroform / 1 h / 15 °C

2.2: 0.5 h / 15 °C

With sodium hydroxide; isobutyl chloroformate; In ethanol; chloroform;
DOI:10.1021/jm2001597

Reference yield:

7-chloro-5-(4-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one: 5571-60-8
7-chloro-5-(4-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

: 1318262-18-8
8-chloro-6-(4-chlorophenyl)-N-methyl-4H-imidazo[1,5-a]-[1,4]benzodiazepine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

1.3: 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide / ethanol / 0.5 h / Reflux

3.1: isobutyl chloroformate / chloroform / 1 h / 15 °C

3.2: 0.5 h / 15 °C

With potassium tert-butylate; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jm2001597