2-((5-chloro-2-((2-methoxy-5-nitrophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Name:2-((5-chloro-2-((2-methoxy-5-nitrophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1346448-08-5
Molecular Formula:C₂₇H₃₂ClN₇O₅Si
Molecular Weight:598.133
Hs Code.:

Synonyms:2-((5-chloro-2-((2-methoxy-5-nitrophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((5-chloro-2-((2-methoxy-5-nitrophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((5-chloro-2-((2-methoxy-5-nitrophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

There total 6 articles about 2-((5-chloro-2-((2-methoxy-5-nitrophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1346448-07-4
2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

: 99-59-2
3-amino-4-methoxynitrobenzene

: 1346448-08-5
2-((5-chloro-2-((2-methoxy-5-nitrophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tert-butyl alcohol; at 85 ℃; for 14h;

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1346448-08-5
2-((5-chloro-2-((2-methoxy-5-nitrophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 48 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide

2.2: 1 h / 0 - 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.5 h / 20 °C

4.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 14 h / 85 °C

With N-chloro-succinimide; potassium tert-butylate; sodium hydride; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 118-48-9
isatoic anhydride

: 1346448-08-5
2-((5-chloro-2-((2-methoxy-5-nitrophenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,4-dioxane / 0.33 h

2: potassium tert-butylate / N,N-dimethyl-formamide / 1.5 h / 20 °C

3: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 14 h / 85 °C

With potassium tert-butylate; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol;