2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Base Information

Chemical Name:2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1346448-07-4
Molecular Formula:C₂₀H₂₅Cl₂N₅O₂Si
Molecular Weight:466.442
Hs Code.:

Synonyms:2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

There total 4 articles about 2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1313036-72-4
2,4,5-trichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

: 4141-08-6
2-Amino-N-methylbenzamid

: 1346448-07-4
2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield:

: 1053228-28-6
2,4,5-trichloro-7H-pyrrolo [2,3-d] pyrimidine

: 1346448-07-4
2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide

1.2: 1 h / 0 - 20 °C

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.5 h / 20 °C

With potassium tert-butylate; sodium hydride; In N,N-dimethyl-formamide;

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1346448-07-4
2-((2,5-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 48 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide

2.2: 1 h / 0 - 20 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 1.5 h / 20 °C

With N-chloro-succinimide; potassium tert-butylate; sodium hydride; In N,N-dimethyl-formamide;