2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzylamine

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Chemical Name:2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzylamine
CAS No.:1048034-92-9
Molecular Formula:C₂₁H₃₀ClN₅O₂S
Molecular Weight:452.02
Hs Code.:

Synonyms:2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzylamine

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Chemical Property of 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzylamine

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Technology Process of 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzylamine

There total 8 articles about 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1048034-91-8
2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

: 1048034-92-9
2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzylamine

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethanol; chloroform; for 18h; under 2585.81 Torr;

Reference yield:

: 1048034-83-8
2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

: 1048034-92-9
2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 108 h

2.1: hydrogenchloride; water / acetone / 18 - 20 h / 55 °C

3.1: acetic acid / dichloromethane / 0.17 h

3.2: 60 h

4.1: hydrogen / platinum(IV) oxide / ethanol; chloroform / 18 h / 2585.81 Torr

With hydrogenchloride; water; hydrogen; caesium carbonate; acetic acid; platinum(IV) oxide; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 1048034-92-9
2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / chloroform; water / 73 h / 0 °C

2.1: toluene-4-sulfonic acid / benzene / 20 h / Heating / reflux

3.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

3.2: 18 h / 0 - 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 108 h

5.1: hydrogenchloride; water / acetone / 18 - 20 h / 55 °C

6.1: acetic acid / dichloromethane / 0.17 h

6.2: 60 h

7.1: hydrogen / platinum(IV) oxide / ethanol; chloroform / 18 h / 2585.81 Torr

With hydrogenchloride; water; hydrogen; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; platinum(IV) oxide; In ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone; benzene;