2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

Base Information

Chemical Name:2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile
CAS No.:1048034-91-8
Molecular Formula:C₂₁H₂₆ClN₅O₂S
Molecular Weight:447.989
Hs Code.:

Synonyms:2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

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Chemical Property of 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

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Technology Process of 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

There total 7 articles about 2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 1048035-05-7
C₁₇H₁₇ClN₄O₃S

: 1048034-91-8
2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

Guidance literature:: pyrrolidine; C₁₇H₁₇ClN₄O₃S; With acetic acid; In dichloromethane; for 0.166667h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 60h;

With sodium hydroxide; water; In dichloromethane;

Reference yield:

: 1048034-93-0
C₁₁H₂₀N₂O₂S

: 1048034-91-8
2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

1.2: 18 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 108 h

3.1: hydrogenchloride; water / acetone / 18 - 20 h / 55 °C

4.1: acetic acid / dichloromethane / 0.17 h

4.2: 60 h

With hydrogenchloride; water; caesium carbonate; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1048034-83-8
2-chloro-5-(5-methanesulfonyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)-benzonitrile

: 1048034-91-8
2-chloro-5-[5-methanesulfonyl-1-(3-pyrrolidin-1-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 108 h

2.1: hydrogenchloride; water / acetone / 18 - 20 h / 55 °C

3.1: acetic acid / dichloromethane / 0.17 h

3.2: 60 h

With hydrogenchloride; water; caesium carbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide; acetone;