(S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N¹-(3-nitro-benzyl)-succinamide

Base Information

• Chemical Name: (S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N¹-(3-nitro-benzyl)-succinamide
• CAS No.: 202653-16-5
• Molecular Formula: C₂₅H₃₁N₅O₇
• Molecular Weight: 513.55

Synonyms:(S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N¹-(3-nitro-benzyl)-succinamide

Chemical Property of (S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N¹-(3-nitro-benzyl)-succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N¹-(3-nitro-benzyl)-succinamide

There total 6 articles about (S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N¹-(3-nitro-benzyl)-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Benzyloxycarbamoyl-4-methyl-pentanoic acid (87438-95-7) + (S)-2-Amino-N1-(3-nitro-benzyl)-succinamide; hydrochloride → (S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N1-(3-nitro-benzyl)-succinamide (202653-16-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 12h; Yield given;

DOI:10.1021/jm9706426

Reference yield:

3-nitrobenzylamine (7409-18-9) → (S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N1-(3-nitro-benzyl)-succinamide (202653-16-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent

2: 4 N aq. HCl / dioxane

3: HOBt, EDCl, Et₃N / tetrahydrofuran / 12 h / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm9706426

Reference yield:

O-benzylhydoxylamine hydrochloride (2687-43-6) → (S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N1-(3-nitro-benzyl)-succinamide (202653-16-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) MeONa, 2.) EDCl, HOBt / 1.) THF, 10 min, 2.) THF, RT, 12 h

2: 85 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 50 °C

3: HOBt, EDCl, Et₃N / tetrahydrofuran / 12 h / 0 - 20 °C

With sodium hydroxide; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/jm9706426

upstream raw materials:

2-Benzyloxycarbamoyl-4-methyl-pentanoic acid

3-nitrobenzylamine

O-benzylhydoxylamine hydrochloride

2-Benzyloxycarbamoyl-4-methylpentanoic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 202653-16-5 (S)-2-(2-Benzyloxycarbamoyl-4-methyl-pentanoylamino)-N¹-(3-nitro-benzyl)-succinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send