N-[(Z)-2-bromo-3-(1-methyl-1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[(Z)-2-bromo-3-(1-methyl-1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide
CAS No.:1342341-02-9
Molecular Formula:C₃₂H₃₉BrN₂O₂S
Molecular Weight:595.644
Hs Code.:

Synonyms:N-[(Z)-2-bromo-3-(1-methyl-1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

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Chemical Property of N-[(Z)-2-bromo-3-(1-methyl-1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

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Technology Process of N-[(Z)-2-bromo-3-(1-methyl-1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

There total 12 articles about N-[(Z)-2-bromo-3-(1-methyl-1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1342341-47-2
N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

: 74-88-4
methyl iodide

: 1342341-02-9
N-[(Z)-2-bromo-3-(1-methyl-1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: N-[(Z)-2-bromo-3-(1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h;
DOI:10.1055/s-0030-1260098

Reference yield:

: (Z)-2-bromo-3-[N-(4-methylphenylsulfonyl)-1H-indol-3-yl]prop-2-en-1-ol

: 1342341-02-9
N-[(Z)-2-bromo-3-(1-methyl-1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 40 °C

2.1: sodium hydride / tetrahydrofuran; ethanol / 9 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 1 h / 0 °C

With di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; mineral oil;
DOI:10.1055/s-0030-1260098

Reference yield:

: N-{(Z)-2-bromo-3-[N-(4-methylphenylsulfonyl)-1H-indol-3-yl]prop-2-enyl}-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

: 1342341-02-9
N-[(Z)-2-bromo-3-(1-methyl-1H-indol-3-yl)prop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; ethanol / 9 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 1 h / 0 °C

With sodium hydride; In tetrahydrofuran; ethanol; mineral oil;
DOI:10.1055/s-0030-1260098