t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate

Base Information

• Chemical Name: t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate
• CAS No.: 1196866-19-9
• Molecular Formula: C₂₆H₃₀ClF₃O₄S
• Molecular Weight: 531.036
• Mol file: 1196866-19-9.mol

Synonyms:t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate

Chemical Property of t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate

There total 1 articles about t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylmalonic acid tert-butyl ester ethyl ester (56834-42-5) + 3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl methanesulfonate (1196866-18-8) → t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate (1196866-19-9)

Guidance literature:

2-methylmalonic acid tert-butyl ester ethyl ester; With sodium t-butanolate; In N,N-dimethyl-formamide; at 8 - 31 ℃; for 0.25h; Inert atmosphere; Industry scale;

3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl methanesulfonate; With sodium iodide; In N,N-dimethyl-formamide; at 50 - 56 ℃; for 3.5h; Inert atmosphere; Industry scale;

Reference yield:

t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate (1196866-19-9) → ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate (1006727-21-4)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 100 - 112 ℃; for 2h; Inert atmosphere; Industry scale;

Reference yield:

t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate (1196866-19-9) → 2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methyl-1-pentanol

Guidance literature:

Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 2 h / 100 - 112 °C / Inert atmosphere; Industry scale

2.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 25 - 38 °C / Industry scale

3.1: toluene / 2.3 h / 75 - 78 °C / Industry scale

3.2: 0.75 h / 7 - 14 °C

4.1: CHIRAL CEL^.(R). OD / isopropyl alcohol; hexane / 40 °C / Resolution of racemate; Industry scale

5.1: sodium hydroxide; water / dimethyl sulfoxide / 4 h / 100 - 116 °C

5.2: 15 - 50 °C / pH 1.3

6.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / 1,2-dimethoxyethane / 3.12 h / 33 - 52 °C

6.2: 25 - 45 °C

6.3: 5 °C / pH 8.5

With sodium tetrahydroborate; diphenyl phosphoryl azide; boron trifluoride diethyl etherate; water; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; In 1,2-dimethoxyethane; hexane; dimethyl sulfoxide; isopropyl alcohol; toluene;

upstream raw materials:

2-methylmalonic acid tert-butyl ester ethyl ester

3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl methanesulfonate

Downstream raw materials:

ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate

ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate

C₂₂H₂₁ClF₃N₃O₃S