ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate

Base Information

• Chemical Name: ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate
• CAS No.: 1006727-21-4
• Molecular Formula: C₂₂H₂₂ClF₃O₄S
• Molecular Weight: 474.928
• Mol file: 1006727-21-4.mol

Synonyms:ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate

Chemical Property of ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate

There total 4 articles about ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methylmalonate (1006727-20-3) → ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate (1006727-21-4)

Guidance literature:

Diethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methylmalonate; With potassium hydroxide; In ethanol; at 50 ℃; for 24h;

With hydrogenchloride; In ethanol; water;

Reference yield:

t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate (1196866-19-9) → ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate (1006727-21-4)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 100 - 112 ℃; for 2h; Inert atmosphere; Industry scale;

Reference yield:

3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl methanesulfonate (1196866-18-8) → ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate (1006727-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium t-butanolate / N,N-dimethyl-formamide / 0.25 h / 8 - 31 °C / Inert atmosphere; Industry scale

1.2: 3.5 h / 50 - 56 °C / Inert atmosphere; Industry scale

2.1: toluene-4-sulfonic acid / toluene / 2 h / 100 - 112 °C / Inert atmosphere; Industry scale

With toluene-4-sulfonic acid; sodium t-butanolate; In N,N-dimethyl-formamide; toluene;

upstream raw materials:

Diethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methylmalonate

2-methylmalonic acid tert-butyl ester ethyl ester

3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl methanesulfonate

t-butyl ethyl 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate

Downstream raw materials:

ethyl (+/-)-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methoxycarbonylamino-2-methylpentanoate

ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate

C₂₂H₂₁ClF₃N₃O₃S