ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate

Base Information

• Chemical Name: ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate
• CAS No.: 1068438-07-2
• Molecular Formula: C₂₄H₂₇ClF₃NO₄S
• Molecular Weight: 517.997
• Mol file: 1068438-07-2.mol

Synonyms:ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate

Chemical Property of ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate

There total 4 articles about ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + C22H21ClF3N3O3S (1196866-20-2) + sodium ethanolate (141-52-6) → ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate (1068438-07-2)

Guidance literature:

C₂₂H₂₁ClF₃N₃O₃S; In toluene; at 75 - 78 ℃; for 2.3h; Industry scale;

ethanol; sodium ethanolate; In toluene; at 7 - 14 ℃; for 0.75h;

Reference yield:

3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl methanesulfonate (1196866-18-8) → ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate (1068438-07-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium t-butanolate / N,N-dimethyl-formamide / 0.25 h / 8 - 31 °C / Inert atmosphere; Industry scale

1.2: 3.5 h / 50 - 56 °C / Inert atmosphere; Industry scale

2.1: toluene-4-sulfonic acid / toluene / 2 h / 100 - 112 °C / Inert atmosphere; Industry scale

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 25 - 38 °C / Industry scale

4.1: toluene / 2.3 h / 75 - 78 °C / Industry scale

4.2: 0.75 h / 7 - 14 °C

With diphenyl phosphoryl azide; toluene-4-sulfonic acid; triethylamine; sodium t-butanolate; In N,N-dimethyl-formamide; toluene;

Reference yield:

ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate (1006727-21-4) → ethyl 5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-ethoxycarbonylamino-2-methyl pentanoate (1068438-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 25 - 38 °C / Industry scale

2.1: toluene / 2.3 h / 75 - 78 °C / Industry scale

2.2: 0.75 h / 7 - 14 °C

With diphenyl phosphoryl azide; triethylamine; In toluene;

upstream raw materials:

ethanol

C₂₂H₂₁ClF₃N₃O₃S

sodium ethanolate

ethyl hydrogen 2-{3-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]propyl}-2-methyl-propane dioate