methyl 2-(4-((2-(5-methylthiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

Base Information

Chemical Name:methyl 2-(4-((2-(5-methylthiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate
CAS No.:1621363-52-7
Molecular Formula:C₂₁H₂₀N₂O₃S
Molecular Weight:380.467
Hs Code.:

Synonyms:methyl 2-(4-((2-(5-methylthiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

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Chemical Property of methyl 2-(4-((2-(5-methylthiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

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Technology Process of methyl 2-(4-((2-(5-methylthiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

There total 5 articles about methyl 2-(4-((2-(5-methylthiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1621363-37-8
2-(4-(2-bromo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methyl ester

: 162607-20-7
(5-methylthiophen-2-yl)boronic acid

: 1621363-52-7
methyl 2-(4-((2-(5-methylthiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In butan-1-ol; at 110 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 5466-43-3
2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine

: 1621363-52-7
methyl 2-(4-((2-(5-methylthiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 2 h / Reflux

2: hydrogen bromide; acetic acid / 4 h / 20 °C

3: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / butan-1-ol / 1.5 h / 110 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; hydrogen bromide; palladium diacetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; butan-1-ol;

Reference yield:

: 5466-00-2
1,5,6,7-tetrahydro-cyclopentapyrimidine-2,4-dione

: 1621363-52-7
methyl 2-(4-((2-(5-methylthiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; sodium hydrogencarbonate / 24 h / 85 - 100 °C / Cooling with ice

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 2 h / Reflux

3: hydrogen bromide; acetic acid / 4 h / 20 °C

4: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / butan-1-ol / 1.5 h / 110 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; hydrogen bromide; palladium diacetate; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In 1,4-dioxane; butan-1-ol;