5-Methylthiophene-2-boronic acid

Base Information

• Chemical Name: 5-Methylthiophene-2-boronic acid
• CAS No.: 162607-20-7
• Molecular Formula: C5H7BO2S
• Molecular Weight: 141.986
• Hs Code.: 29349990
• European Community (EC) Number: 672-308-9
• DSSTox Substance ID: DTXSID90370264
• Nikkaji Number: J1.592.976F
• Wikidata: Q72491452
• Mol file: 162607-20-7.mol

Synonyms:5-Methylthiophene-2-boronic acid;162607-20-7;(5-methylthiophen-2-yl)boronic Acid;5-Methyl-2-thiopheneboronic acid;(5-methyl-2-thienyl)boronic acid;5-methylthiophen-2-ylboronic acid;5-methyl-2-thienylboric acid;5-Methyl-2-thienylboronic Acid;5-methylthiophen-2yl-boronic acid;MFCD01318166;Boronic acid, (5-methyl-2-thienyl)-;5-Methylthiophene-2-boronicacid;2-METHYLTHIOPHENE-5-BORONIC ACID;5-methylthiopheneboronic acid;SCHEMBL130322;5-methylthiophene boronic acid;5-methylthiophen-2-boronic acid;DTXSID90370264;NRIYPIBRPGAWDD-UHFFFAOYSA-N;2-methyl-thiophene-5-boronic acid;5-methyl-2-thiophene-boronic acid;5-methyl-thiophene-2-boronic acid;ETHYL2,4-DIHYDROXYBENZOATE;5-methylthiophene-2-ylboronic acid;(5-methylthiophen-2-yl)boronicAcid;BCP27051;(5-methyl-2-thiophenyl)boronic acid;5-methyl-thiophen-2-yl-boronic acid;5-Methyl-2-thiopheneboronic acid (contains varying amounts of Anhydride);AKOS003585334;CS-W001235;PB21738;PS-9501;AM803287;SY004158;A3616;FT-0620675;M1850;EN300-140712;A810390;J-501600;Z1203159464

Chemical Property of 5-Methylthiophene-2-boronic acid

Chemical Property:

• Appearance/Colour: White to light yellow powder
• Vapor Pressure: 0.000425mmHg at 25°C
• Melting Point: 161.5-166.5 °C(lit.)
• Refractive Index: 1.55
• Boiling Point: 302.9 °C at 760 mmHg
• PKA: 8.73±0.53(Predicted)
• Flash Point: 137 °C
• PSA: 68.70000
• Density: 1.25 g/cm³
• LogP: -0.26370
• Storage Temp.: 0-6°C
• Solubility.: soluble in Methanol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 142.0259808
• Heavy Atom Count: 9
• Complexity: 99

Purity/Quality:

97% ^*data from raw suppliers

5-Methylthiophene-2-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36-7/9-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=CC=C(S1)C)(O)O
• Uses: suzuki reaction Reactant for:Suzuki-Miyaura cross-coupling reactions

Technology Process of 5-Methylthiophene-2-boronic acid

There total 1 articles about 5-Methylthiophene-2-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methylthiophene (476004-80-5) → 2-Methylthiophene (554-14-3) + (5-methylthiophen-2-yl)boronic acid (162607-20-7)

Guidance literature:

With sodium carbonate; In 1,2,3-trimethoxybenzene; water; at 20 ℃; for 5h;

DOI:10.1021/ol301570t

Reference yield: 95.0%

4-chloro-6-(4-methoxybenzyloxy)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine (1251166-18-3) + (5-methylthiophen-2-yl)boronic acid (162607-20-7) → 4-(4-methoxybenzyloxy)-6-(5-methylthiophen-2-yl)-2-(4-trifluoromethylthiazol-2-yl)pyrimidine (1251166-34-3)

Guidance literature:

With sodium carbonate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Irradiation;

Reference yield: 87.52%

4-(4-iodo-3-nitrophenyl)-5-methylisothiazole + (5-methylthiophen-2-yl)boronic acid (162607-20-7) → 5-methyl-4-(4-(5-methylthiophen-2-yl)-3-nitrophenyl)isothiazole

Guidance literature:

With sodium carbonate; In water; N,N-dimethyl-formamide; at 140 ℃; for 0.583333h; Microwave irradiation;

upstream raw materials:

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methylthiophene

Downstream raw materials:

5-methyl-2-(phenylethynyl)thiophene

2-(5-methylthiophene-2-yl)pyridine

2,5-di(5-methylthiophen-2-yl)pyridine

5-methyl-2,2'-bithiophene-5'-carboxaldehyde