162607-20-7

Basic information

• Product Name: 5-Methylthiophene-2-boronic acid
• Synonyms: RARECHEM AH PB 0219;TIMTEC-BB SBB004150;CHEMBRDG-BB 3200980;AKOS BRN-0271;5-METHYL-2-THIENYLBORIC ACID;5-METHYL-2-THIENYLBORONIC ACID;5-METHYL-2-THIOPHENEBORONIC ACID;5-METHYLTHIOPHENE-2-BORONIC ACID
• CAS NO: 162607-20-7
• Molecular Formula: C₅H₇BO₂S
• Molecular Weight: 141.98
• EINECS: -0
• Product Categories: Azoles;blocks;BoronicAcids;Thiophene&Benzothiophene;Boronic acids;Boronic acid;Organoborons;Thiophene;B (Classes of Boron Compounds);Boronic Acids;Boronic Acids and Derivatives;Heteroaryl;Boric Acid| Boric Acid Ester| Potassium Trifluoroborate
• Mol File: 162607-20-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 161.5-166.5 °C(lit.)
• Boiling Point: 302.9 °C at 760 mmHg
• Flash Point: 137 °C
• Appearance: White to light yellow powder
• Density: 1.25 g/cm³
• Vapor Pressure: 0.000425mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: 0-6°C
• Solubility: soluble in Methanol
• PKA: 8.73±0.53(Predicted)
• BRN: 7019569
• CAS DataBase Reference: 5-Methylthiophene-2-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methylthiophene-2-boronic acid(162607-20-7)
• EPA Substance Registry System: 5-Methylthiophene-2-boronic acid(162607-20-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36-7/9-37
• WGK Germany: 3
• HazardClass: IRRITANT, KEEP COLD
• Hazardous Substances Data: 162607-20-7(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow powder

Uses

Different sources of media describe the Uses of 162607-20-7 differently. You can refer to the following data:
1. suzuki reaction
2. Reactant for:Suzuki-Miyaura cross-coupling reactions

InChI:InChI=1/C5H7BO2S/c1-4-2-3-5(9-4)6(7)8/h2-3,7-8H,1H3

Upstream product

• 476004-80-5 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methylthiophene 

Downstream Products

• 92070-90-1 5-methyl-2-(phenylethynyl)thiophene 
• 139003-60-4 2-(5-methylthiophene-2-yl)pyridine 
• 624744-81-6 2,5-di(5-methylthiophen-2-yl)pyridine 
• 32358-94-4 5-methyl-2,2'-bithiophene-5'-carboxaldehyde 
• 952289-10-0 1,1-Dimethylethyl (2R,6S)-4-[6-({[2-chloro-4-(5-methyl-2-thienyl)phenyl]sulfonyl}amino)-5-(methyloxy)-2-pyridinyl]-2,6-dimethyl-1-piperazinecarboxylate 
• 552845-81-5 2,4-dimethoxy-5-(5-methyl-thien-2-yl)-benzaldehyde 
• 749927-71-7 2-(4-Bromo-2-fluoro-phenyl)-5-methyl-thiophene 
• 328920-02-1 2-(4-{2-[2-(4-{5 '-methylthiophen-2-yl}-phenyl)-5-methyloxazol-4-yl]ethoxy}phenoxy)-2-methylpropionic acid ethyl ester 
• 1146977-12-9 1-(3-cyclopropyl-4-methyl-2-{[4-(5-methyl-2-thienyl)phenyl]imino}-2,3-dihydro-1,3-thiazol-5-yl)ethanone 
• 1089758-30-4 C₄₀H₂₇OPS₄ 
• 1189330-06-0 4-(5-methylthiophen-2-yl)-2-(p-tosylmethyl)quinazoline 
• 1219628-31-5 1-(2-(4-(6-methoxy-2-(5-methylthiophen-2-yl)naphthalen-1-yloxy)phenoxy)ethyl)piperidine hydrochloride 

Relevant articles and documents

A C-H borylation approach to suzuki-miyaura coupling of typically unstable 2-heteroaryl and polyfluorophenyl boronates

A method for the synthesis of biaryls and heterobiaryls from arenes and haloarenes without the intermediacy of unstable boronic acids is described. Pinacol boronate esters that are analogous to unstable boronic acids are formed in high yield by iridium-catalyzed C-H borylation of heteroarenes and fluoroarenes. These boronates are stable in the solid state or in solution and can be generated and used in situ. They couple with aryl halides in the presence of simple palladium catalysts, providing a convenient route to biaryl and heteroaryl products that have been challenging to prepare via boronic acids.