tert-butyl 4-(2-(benzhydryloxy)ethyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(2-(benzhydryloxy)ethyl)piperazine-1-carboxylate
• CAS No.: 1065099-83-3
• Molecular Formula: C₂₄H₃₂N₂O₃
• Molecular Weight: 396.53
• Mol file: 1065099-83-3.mol

Synonyms:tert-butyl 4-(2-(benzhydryloxy)ethyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(2-(benzhydryloxy)ethyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(2-(benzhydryloxy)ethyl)piperazine-1-carboxylate

There total 4 articles about tert-butyl 4-(2-(benzhydryloxy)ethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

1,1-Diphenylmethanol (91-01-0) + tert-butyl 4-(2-iodoethyl)piperazine-1-carboxylate (1345012-35-2) → tert-butyl 4-(2-(benzhydryloxy)ethyl)piperazine-1-carboxylate (1065099-83-3)

Guidance literature:

1,1-Diphenylmethanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

tert-butyl 4-(2-iodoethyl)piperazine-1-carboxylate; In N,N-dimethyl-formamide; mineral oil; at 110 ℃; for 6h;

DOI:10.1016/j.bmcl.2011.09.001

Reference yield:

1-(2-hydroxyethyl)piperazine (103-76-4) → tert-butyl 4-(2-(benzhydryloxy)ethyl)piperazine-1-carboxylate (1065099-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 1 h / 20 °C

2.1: iodine; triphenylphosphine / dichloromethane / 20 h

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3.2: 6 h / 110 °C

With iodine; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmcl.2011.09.001

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(2-(benzhydryloxy)ethyl)piperazine-1-carboxylate (1065099-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 1 h / 20 °C

2.1: iodine; triphenylphosphine / dichloromethane / 20 h

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3.2: 6 h / 110 °C

With iodine; sodium hydride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmcl.2011.09.001

upstream raw materials:

1-(2-hydroxyethyl)piperazine

1,1-Diphenylmethanol

tert-butyl 4-(2-iodoethyl)piperazine-1-carboxylate

di-tert-butyl dicarbonate

Downstream raw materials:

1-[2-(diphenylmethoxy)ethyl]piperazine