(S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(2-(dimethylamino)-ethylsulfonamido)benzoate

Base Information

Chemical Name:(S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(2-(dimethylamino)-ethylsulfonamido)benzoate
CAS No.:1610861-26-1
Molecular Formula:C₃₃H₃₇Cl₂F₂N₃O₇S
Molecular Weight:728.641
Hs Code.:

(S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(2-(dimethylamino)-ethylsulfonamido)benzoate

Synonyms:(S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(2-(dimethylamino)-ethylsulfonamido)benzoate

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Chemical Property of (S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(2-(dimethylamino)-ethylsulfonamido)benzoate

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Technology Process of (S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(2-(dimethylamino)-ethylsulfonamido)benzoate

There total 11 articles about (S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(2-(dimethylamino)-ethylsulfonamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1610861-27-2
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

: 1610861-26-1
(S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(2-(dimethylamino)-ethylsulfonamido)benzoate

Guidance literature:: With ammonium chloride; zinc; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 1610861-26-1
(S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(2-(dimethylamino)-ethylsulfonamido)benzoate

Guidance literature:: Multi-step reaction with 10 steps

1: sulfuric acid / water / 144 h / 60 °C

2: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 775.74 Torr

4: pyridine / dichloromethane / 1 h / 0 - 20 °C

5: ethanol / 1 h / 20 °C

6: dmap / dichloromethane / 1 h / 20 °C

7: water; lithium hydroxide / 24 h / 20 °C

8: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

9: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

10: ammonium chloride; zinc / tetrahydrofuran; water / 0.5 h / 20 °C

With pyridine; hydrogenchloride; dmap; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; lithium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1154342-13-8
methyl 4-amino-3-(cyclopropylmethoxy)benzoate

: 1610861-26-1
(S)-1-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3,5-dichloropyridin-4-yl)ethyl 3-(cyclopropylmethoxy)-4-(2-(dimethylamino)-ethylsulfonamido)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C

2: ethanol / 1 h / 20 °C

3: dmap / dichloromethane / 1 h / 20 °C

4: water; lithium hydroxide / 24 h / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

6: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

7: ammonium chloride; zinc / tetrahydrofuran; water / 0.5 h / 20 °C

With pyridine; hydrogenchloride; dmap; water; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;