(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide
CAS No.:1610861-27-2
Molecular Formula:C₃₃H₃₇Cl₂F₂N₃O₈S
Molecular Weight:744.641
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

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Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

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Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

There total 10 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1610861-29-4
(S)-4-(2-(4-(N-(tert-butoxycarbonyl)-2-(dimethylamino)-ethylsulfonamido)-3-(cyclopropylmethoxy)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide

: 1610861-27-2
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃;

Reference yield:

: 1154342-13-8
methyl 4-amino-3-(cyclopropylmethoxy)benzoate

: 1610861-27-2
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / dichloromethane / 1 h / 0 - 20 °C

2: ethanol / 1 h / 20 °C

3: dmap / dichloromethane / 1 h / 20 °C

4: water; lithium hydroxide / 24 h / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

6: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

With pyridine; hydrogenchloride; dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 1610861-27-2
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(2-(dimethylamino)ethylsulfonamido)benzoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid / water / 144 h / 60 °C

2: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 775.74 Torr

4: pyridine / dichloromethane / 1 h / 0 - 20 °C

5: ethanol / 1 h / 20 °C

6: dmap / dichloromethane / 1 h / 20 °C

7: water; lithium hydroxide / 24 h / 20 °C

8: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

9: hydrogenchloride / dichloromethane; 1,4-dioxane / 20 °C

With pyridine; hydrogenchloride; dmap; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; lithium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;