(R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate

Base Information

Chemical Name:(R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate
CAS No.:1331782-39-8
Molecular Formula:C₇H₈O₃S*C₁₇H₂₂N₂O₄
Molecular Weight:490.577
Hs Code.:

Synonyms:(R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate

Chemical Property:

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Technology Process of (R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate

There total 18 articles about (R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1331782-36-5
4-{4-[(R)-(tetrahydrofuran-3-yl)oxy]-benzo[d]-isoxazol-3-yloxymethyl}-piperidine-1-carboxylate tert-butyl ester

: 104-15-4
toluene-4-sulfonic acid

: 1331782-39-8
(R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate

Guidance literature:: In ethyl acetate; at 20 - 65 ℃; for 17.5h;

Reference yield:

: 154714-19-9
5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 1331782-39-8
(R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18 h / 20 °C

2: potassium carbonate / 2 h / 20 °C

3: hydroxyammonium sulfate; potassium carbonate; sodium sulfite / water; methanol / 30 h / 50 °C

4: 1,1'-carbonyldiimidazole / tetrahydrofuran / 14 h / 50 °C

5: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 18 h / Reflux

6: ethyl acetate / 17.5 h / 20 - 65 °C

With hydroxyammonium sulfate; potassium carbonate; triphenylphosphine; 1,1'-carbonyldiimidazole; sodium sulfite; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

: 67531-86-6
6-fluorosalicylic acid

: 1331782-39-8
(R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 45 h / 60 °C

2.1: hydroxyammonium sulfate; potassium carbonate / water; methanol / 21.5 h / 15 - 35 °C / Industry scale

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 7 h / 25 - 60 °C

3.2: 1.25 h / 15 - 20 °C / pH 1

4.1: potassium carbonate / ISOPROPYLAMIDE / 20 h / 50 °C / Industry scale

5.1: sodium hexamethyldisilazane / ISOPROPYLAMIDE; tetrahydrofuran / 20 - 30 °C

5.2: 16 h / 25 °C

6.1: ethyl acetate / 17.5 h / 20 - 65 °C

With hydroxyammonium sulfate; sulfuric acid; sodium hexamethyldisilazane; potassium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; ISOPROPYLAMIDE; water; ethyl acetate;