Technology Process of (3S)-(1E,5Z)-3-O-((tert-butyldiphenylsilyl)oxy)-1-iodo-1,5-undecadiene
There total 6 articles about (3S)-(1E,5Z)-3-O-((tert-butyldiphenylsilyl)oxy)-1-iodo-1,5-undecadiene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chromium dichloride;
In
tetrahydrofuran;
at 0 ℃;
for 18h;
DOI:10.1021/ja00128a008
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaHMDS / 1.) THF, RT, 15 min, 2.) THF, from -78 deg C to RT, 18 h
2: 72 percent / aq. TFA / tetrahydrofuran / 10 h / 70 °C
3: 89 percent / Pb(OAc)4, Na2CO3 / CH2Cl2 / 0.25 h / -78 °C
4: 57 percent / CrCl2 / tetrahydrofuran / 18 h / 0 °C
With
chromium dichloride; lead(IV) acetate; sodium hexamethyldisilazane; sodium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00128a008
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 72 percent / aq. TFA / tetrahydrofuran / 10 h / 70 °C
2: 89 percent / Pb(OAc)4, Na2CO3 / CH2Cl2 / 0.25 h / -78 °C
3: 57 percent / CrCl2 / tetrahydrofuran / 18 h / 0 °C
With
chromium dichloride; lead(IV) acetate; sodium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00128a008