100428-41-9

Upstream product

• 131392-94-4 2S-(t-butyldiphenylsilyloxy)dec-4Z-en-1-ol 
• 100311-69-1 (Z)-(2S,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-undec-5-ene-1,2-diol 
• 100333-62-8 (2R,3S)-(Z)-3-O-(tert-butyldiphenylsilyl)-5-undecene-1,2,3-triol 
• 95646-05-2 3(S)-<(tert-butyldiphenylsilyl)oxy>-1,2-bis-O-(isopropylidene)-5(Z)-undecene-1,2(R)-diol 
• 93292-42-3 2-deoxy-3-O-(tert-butyldiphenylsilyl)-4,5-bis-O-(1-methylethylidene)-D-erythro-pentose 
• 93292-41-2 2-deoxy-3-O-(tert-butyldiphenylsilyl)-4,5-O-isopropylidene-D-erythro-pentose diethyl dithioacetal 
• 4762-26-9 hexyltriphenylphosphonium bromide 
• 16666-79-8 hexylidenetriphenylphosphoran 
• 85593-60-8 (R)-3-(tert-Butyl-diphenyl-silanyloxy)-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propionaldehyde 
• 85593-59-5 tert-Butyl-[(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-bis-ethylsulfanyl-propoxy]-diphenyl-silane 
• 100311-68-0 tert-Butyl-[(Z)-(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-non-3-enyloxy]-diphenyl-silane 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 66348-35-4 (2S)-1,2-dihydroxydec-4Z-ene 
• 66348-34-3 2,2-dimethyl-4-oct-2Z-enyl-(S)-1,3-dioxolane 

Downstream Products

• 100311-74-8 <(tert-butyldiphenylsilyl)oxy>-2(E),6(Z)-decedienal 
• 90108-36-4 (6E,8Z,10E,14Z)-(S)-5,12-Bis-(tert-butyl-diphenyl-silanyloxy)-icosa-6,8,10,14-tetraenoic acid methyl ester 
• 164932-95-0 (3S)-(1E,5Z)-3-O-((tert-butyldiphenylsilyl)oxy)-1-iodo-1,5-undecadiene 
• 218162-92-6 ethyl-4(S)-<(tert-butyldiphenylsilyl)oxy>-2(E),6(Z)-dodecadienoate 
• 218162-93-7 4(S)-<(tert-butyldiphenylsilyl)oxy>-2(E),6(Z)-dodecadienyl-1-ol 
• 218162-94-8 methyl-5,5-(dimethylenedithio)-12(S)-<(tert-butyldiphenylsilyl)oxy>-6(E),10(E),14(Z)-eicosatetraenoate 
• 54397-83-0 12-hydroxyeicosatetraenoic acid 
• 100311-78-2 (5Z,8Z,10E,14Z)-(S)-12-(tert-Butyl-diphenyl-silanyloxy)-icosa-5,8,10,14-tetraenoic acid 
• 100311-67-9 methyl 12(S)-<(tert-butyldiphenylsilyl)oxy>-5(Z),8,10(E),14(Z)-eicosatetraenoate 
• 70578-51-7 (6E,8Z,10E,14Z)-(S)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenoic acid 
• 70578-51-7 (5S,12S,6E,8Z,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid 
• 79065-10-4 (6E,8Z,10Z,14Z)-(5S,12S)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenoic acid methyl ester 
• 79065-10-4 (6E,8Z,10Z,14Z)-(5R,12S)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenoic acid methyl ester 
• 82493-56-9 [(2E,4E,8Z)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trienyl]-triphenyl-phosphonium; bromide 

Relevant academic research and scientific papers

The total synthesis of 5-oxo-12(s)-hydroxy-6(e),8(z),10(e),14(z)- eicosatetraenoic acid and its 8,9-trans-isomer and their identification in human platelets

The first total synthesis of 5-oxo-12(S)-hydroxy-6(E),8(Z),10(E), 14(Z)- eicosatetraenoic acid (5-oxo-12-HETE) 6 and its 8-trans-isomer 7 is reported. The synthetic 5-oxo-12-HETE 6 and its 8,9-trans-isomer 7 were used to identify their formation in mixtures of platelets and neutrophils by transcellular metabolism.

Cyclopropane-containing eicosanoids of marine origin. Biomimetic synthesis of constanolactones A and B from the alga Constaninea simplex

Asymmetric syntheses of 7, a substance isolated from incubation of arachidonic acid with an acetone powder of the coral Plexaura homomalla, and of constanolactones A (9) and B (10), metabolites of the red alga Constantinea simplex, are described. The key

A new practical enantiospecific synthesis of unlabelled and tritium labelled 12-HETEs

The oxidative metabolism of arachidonic acid AA is known to yield a variety of biologically active substances.Among them, both enantiomers of 12-hydroxyeicosatetraenoic acid (12-HETE) have been the subject of much interest.In order to extend their biologi

The Total Synthesis of 12-HETE and 12,20-DiHETE

The total syntheses of 12-HETE (1) in racemic form and of both enantiomers in optically pure form are reported.The synthesis of a metabolite of 12(S)-HETE, 12,20-diHETE (2), in optically pure form is also reported.

SIMPLE EFFICIENT SYNTHESIS OF LTB4 AND 12-epi-LTB4

Using L- and D-arabinose respectively as the source of chirality at C-12 in LTB4, efficient new syntheses of LTB4 and 12-epi-LTB4 have been realized.