100428-41-9Relevant articles and documents
The total synthesis of 5-oxo-12(s)-hydroxy-6(e),8(z),10(e),14(z)- eicosatetraenoic acid and its 8,9-trans-isomer and their identification in human platelets
Khanapure, Subhash P.,Powell, William S.,Rokach, Joshua
, p. 8976 - 8982 (2007/10/03)
The first total synthesis of 5-oxo-12(S)-hydroxy-6(E),8(Z),10(E), 14(Z)- eicosatetraenoic acid (5-oxo-12-HETE) 6 and its 8-trans-isomer 7 is reported. The synthetic 5-oxo-12-HETE 6 and its 8,9-trans-isomer 7 were used to identify their formation in mixtures of platelets and neutrophils by transcellular metabolism.
A new practical enantiospecific synthesis of unlabelled and tritium labelled 12-HETEs
Mosset, P.,Pointeau, P.,Aubert, F.,Lellouche, J. P.,Beaucourt, J. P.,Gree, R.
, p. 298 - 315 (2007/10/02)
The oxidative metabolism of arachidonic acid AA is known to yield a variety of biologically active substances.Among them, both enantiomers of 12-hydroxyeicosatetraenoic acid (12-HETE) have been the subject of much interest.In order to extend their biologi
SIMPLE EFFICIENT SYNTHESIS OF LTB4 AND 12-epi-LTB4
Zamboni, Robert,Rokach, Joshua
, p. 2631 - 2634 (2007/10/02)
Using L- and D-arabinose respectively as the source of chirality at C-12 in LTB4, efficient new syntheses of LTB4 and 12-epi-LTB4 have been realized.