(2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-(4-benzyloxyphenyl) propanoic acid 2-(trimethylsilyl)ethyl ester

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Chemical Name:(2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-(4-benzyloxyphenyl) propanoic acid 2-(trimethylsilyl)ethyl ester
CAS No.:374803-68-6
Molecular Formula:C₄₀H₅₁NO₆Si₂
Molecular Weight:698.019
Hs Code.:

Synonyms:(2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-(4-benzyloxyphenyl) propanoic acid 2-(trimethylsilyl)ethyl ester

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Chemical Property of (2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-(4-benzyloxyphenyl) propanoic acid 2-(trimethylsilyl)ethyl ester

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Technology Process of (2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-(4-benzyloxyphenyl) propanoic acid 2-(trimethylsilyl)ethyl ester

There total 5 articles about (2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-(4-benzyloxyphenyl) propanoic acid 2-(trimethylsilyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 374803-66-4
(S)-2-[2-Benzoyl-4-(2-trimethylsilanyl-ethoxymethoxy)-phenylamino]-3-(4-benzyloxy-phenyl)-propionic acid

: 374803-68-6
(2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-(4-benzyloxyphenyl) propanoic acid 2-(trimethylsilyl)ethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In ethyl acetate; at 25 ℃; for 18h;
DOI:10.1016/S0040-4020(01)00743-8

Reference yield:

: 60080-98-0
(2-bromo-5-methoxyphenyl)(phenyl)methanone

: 374803-68-6
(2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-(4-benzyloxyphenyl) propanoic acid 2-(trimethylsilyl)ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: BCl₃; nBu₄NI / CH₂Cl₂ / 14 h / -78 - 25 °C

2: 11.3 g / iPr₂NEt / CH₂Cl₂ / 18 h / 25 °C

3: 50 percent / K₂CO₃; CuI / dimethylformamide / 72 h / 90 °C

4: 71 percent / DCC; DMAP / ethyl acetate / 18 h / 25 °C

With dmap; copper(l) iodide; boron trichloride; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00743-8

Reference yield:

: 35450-36-3
methyl 2-bromo-5-methoxybenzoate

: 374803-68-6
(2S)-2-[(2-benzoyl-4-{[2-(trimethylsilyl)ethoxy]methoxy}phenyl)amino]-3-(4-benzyloxyphenyl) propanoic acid 2-(trimethylsilyl)ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: PhMgCl / tetrahydrofuran / 1 h / -5 °C

2: 37.4 g / tetrahydrofuran / 5 h / -10 - 25 °C

3: BCl₃; nBu₄NI / CH₂Cl₂ / 14 h / -78 - 25 °C

4: 11.3 g / iPr₂NEt / CH₂Cl₂ / 18 h / 25 °C

5: 50 percent / K₂CO₃; CuI / dimethylformamide / 72 h / 90 °C

6: 71 percent / DCC; DMAP / ethyl acetate / 18 h / 25 °C

With dmap; copper(l) iodide; phenylmagnesium chloride; boron trichloride; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00743-8