2-acetylamino-6-formyl-4-methylphenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 2-acetylamino-6-formyl-4-methylphenyl trifluoromethanesulfonate
• CAS No.: 868050-16-2
• Molecular Formula: C₁₁H₁₀F₃NO₅S
• Molecular Weight: 325.265
• Mol file: 868050-16-2.mol

Synonyms:2-acetylamino-6-formyl-4-methylphenyl trifluoromethanesulfonate

Chemical Property of 2-acetylamino-6-formyl-4-methylphenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetylamino-6-formyl-4-methylphenyl trifluoromethanesulfonate

There total 2 articles about 2-acetylamino-6-formyl-4-methylphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(3-formyl-2-hydroxy-5-methyl-phenyl)-acetamide (868050-23-1) + N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) → 2-acetylamino-6-formyl-4-methylphenyl trifluoromethanesulfonate (868050-16-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tet.2005.08.004

Reference yield:

2-hydroxy-5-methyl-3-nitro-benzaldehyde (66620-31-3) → 2-acetylamino-6-formyl-4-methylphenyl trifluoromethanesulfonate (868050-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / H₂ / Pd/C / ethyl acetate / 20 °C

2: 95 percent / K₂CO₃ / tetrahydrofuran / 20 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/j.tet.2005.08.004

Reference yield: 86.0%

2-acetylamino-6-formyl-4-methylphenyl trifluoromethanesulfonate (868050-16-2) + phenylacetylene (536-74-3) → N-[3-formyl-5-methyl-2-(phenylethynyl)phenyl]acetamide (868050-17-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 55 ℃; for 6h;

DOI:10.1016/j.tet.2005.08.004

upstream raw materials:

N-(3-formyl-2-hydroxy-5-methyl-phenyl)-acetamide

N,N-phenylbistrifluoromethane-sulfonimide

2-hydroxy-5-methyl-3-nitro-benzaldehyde

Downstream raw materials:

N-[3-formyl-5-methyl-2-(phenylethynyl)phenyl]acetamide

N-[3-formyl-5-methyl-2-(trimethylsilylethynyl)phenyl]acetamide

6-methylindole-4-carboxaldehyde