6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one

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Chemical Name:6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one
CAS No.:1431323-88-4
Molecular Formula:C₂₅H₂₄Cl₂N₆O
Molecular Weight:495.411
Hs Code.:

Synonyms:6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one

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Chemical Property of 6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one

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Technology Process of 6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one

There total 15 articles about 6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 16153-81-4
4-(4-Methyl-piperazino)-anilin

: 1431323-90-8
6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one

: 1431323-88-4
6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one

Guidance literature:: 6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene; at 0 ℃; for 0.333333h; Inert atmosphere;

4-(4-Methyl-piperazino)-anilin; With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 60 ℃; for 16h; Inert atmosphere;

Reference yield:

: 16153-81-4
4-(4-Methyl-piperazino)-anilin

: C₁₅H₁₁Cl₂N₃O₃S

: 1431323-88-4
6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one

Guidance literature:: With trifluoroacetic acid; In acetonitrile; for 16h; Heating;
DOI:10.1016/j.bmcl.2019.04.017

Reference yield:

: 1431323-89-5
2-(2,6-dichlorophenyl)-1-(4-(methylamino)-2-(methylthio)pyrimidin-5-yl)ethanone

: 1431323-88-4
6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-5(8H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.2 h / 150 °C / Microwave irradiation

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.33 h / 20 °C

2.2: 16 h / 90 °C

2.3: 20 °C

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;