6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one

Base Information

Chemical Name:6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one
CAS No.:1431323-90-8
Molecular Formula:C₁₅H₁₁Cl₂N₃OS
Molecular Weight:352.244
Hs Code.:

Synonyms:6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one

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Chemical Property of 6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one

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Technology Process of 6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one

There total 12 articles about 6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1431323-89-5
2-(2,6-dichlorophenyl)-1-(4-(methylamino)-2-(methylthio)pyrimidin-5-yl)ethanone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1431323-90-8
6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one

Guidance literature:: Microwave irradiation; Heating;
DOI:10.1016/j.bmcl.2019.04.017

Reference yield: 10.0%

: 6-iodo-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one

: 73852-17-2
2,6-dichlorophenylboronic acid

: 1431323-90-8
6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one

Guidance literature:: 6-iodo-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one; 2,6-dichlorophenylboronic acid; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; at 80 ℃; for 16h; Sealed tube;

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; at 90 ℃; for 16h;

Reference yield:

: 55084-66-7
4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride

: 1431323-90-8
6-(2,6-dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) cyanide; lithium chloride / tetrahydrofuran / 0.25 h / -25 °C

1.2: 1.67 h / -25 - 20 °C / Inert atmosphere

2.1: isopropyl alcohol / 2.5 h / 50 °C / Sealed tube

3.1: 0.2 h / 150 °C / Microwave irradiation

With copper(l) cyanide; lithium chloride; In tetrahydrofuran; isopropyl alcohol;