4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride

Base Information

Chemical Name:4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride
CAS No.:55084-66-7
Molecular Formula:C6H4Cl2N2OS
Molecular Weight:223.083
Hs Code.:2933599590
European Community (EC) Number:815-867-8
Nikkaji Number:J2.599.599F
Mol file:55084-66-7.mol

Synonyms:55084-66-7;4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride;4-CHLORO-2-METHYLMERCAPTOPYRIMIDINE-5-CARBOXYLIC ACID CHLORIDE;5-Pyrimidinecarbonyl chloride, 4-chloro-2-(methylthio)-;4-chloro-2-methylsulfanylpyrimidine-5-carbonyl chloride;MFCD12545984;4-Chloro-2-(methylthio)-5-pyrimidinecarbonyl chloride;4-CHLORO-2-(METHYLSULFANYL)PYRIMIDINE-5-CARBONYL CHLORIDE;SCHEMBL5656811;NMFCRGDGVPCDHH-UHFFFAOYSA-N;AKOS015995993;DA-39676;DS-19065;SY130861;EN300-323020;2-methylthio-4-chloropyrimidine-5-carbonylchloride;2-(Methylthio)-4-chloropyrimidine-5-carbonyl chloride;4-chloro-2-(methylthio)pyrimidine-5-carbonylchloride

Suppliers and Price of 4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-2-methylsulfanylpyrimidine-5-carboxylicAcidChloride
500mg
$ 90.00

TRC
4-Chloro-2-methylsulfanylpyrimidine-5-carboxylicAcidChloride
50mg
$ 45.00

Crysdot
4-Chloro-2-(methylthio)pyrimidine-5-carbonylchloride 95%
5g
$ 148.00

Chemenu
4-Chloro-2-(methylthio)pyrimidine-5-carbonylchloride 95%
5g
$ 153.00

Chemenu
4-Chloro-2-(methylthio)pyrimidine-5-carbonylchloride 95%
25g
$ 421.00

Chemenu
4-Chloro-2-(methylthio)pyrimidine-5-carbonylchloride 95%
10g
$ 224.00

Alichem
4-Chloro-2-(methylthio)pyrimidine-5-carbonylchloride
25g
$ 441.00

Alichem
4-Chloro-2-(methylthio)pyrimidine-5-carbonylchloride
5g
$ 157.50

Alichem
4-Chloro-2-(methylthio)pyrimidine-5-carbonylchloride
10g
$ 249.60

AK Scientific
4-Chloro-2-(methylthio)pyrimidine-5-carbonylchloride
5g
$ 228.00

Total 13 raw suppliers

Chemical Property of 4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride

Chemical Property:

Boiling Point:326.3±22.0 °C(Predicted)
PKA:-2.80±0.29(Predicted)
PSA：91.21000
Density:1.56±0.1 g/cm3(Predicted)
LogP:1.01740
Storage Temp.:Inert atmosphere,Store in freezer, under -20°C
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:221.9421393
Heavy Atom Count:12
Complexity:181

Purity/Quality:

≥99%HPLC ^*data from raw suppliers

4-Chloro-2-methylsulfanylpyrimidine-5-carboxylicAcidChloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSC1=NC=C(C(=N1)Cl)C(=O)Cl

Technology Process of 4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride

There total 4 articles about 4-Chloro-2-(methylthio)pyrimidine-5-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 397308-78-0
4-hydroxy-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

: 55084-66-7
4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; at 90 ℃; for 3h;
DOI:10.1016/j.bmcl.2019.04.017

Reference yield: 99.0%

: 74840-34-9
4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

: 55084-66-7
4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; at 90 ℃; for 3h;
DOI:10.1016/j.bmcl.2019.04.017

Reference yield:

: 53554-29-3
ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate

: 55084-66-7
4-chloro-2-(methylthio)pyrimidine-5-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; water

2: thionyl chloride

With thionyl chloride; water; potassium hydroxide;