Technology Process of 7-(azidomethyl)-4-(3-fluorophenyl)-2H-chromen-2-one
There total 8 articles about 7-(azidomethyl)-4-(3-fluorophenyl)-2H-chromen-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
7-(bromomethyl)-4-(3-fluorophenyl)-2H-chromen-2-one;
With
sodium azide;
In
ethanol;
at 60 ℃;
for 3h;
With
water;
In
ethanol;
at 10 - 15 ℃;
for 1h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydroxide
2: aluminum (III) chloride / toluene / 90 °C
3: potassium 2-methylbutan-2-olate / 100 °C
4: palladium diacetate; sodium carbonate
5: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 2 h / 78 - 82 °C / Large scale reaction
6: sodium azide / ethanol / 3 h / 60 °C / Large scale reaction
With
aluminum (III) chloride; N-Bromosuccinimide; sodium azide; palladium diacetate; potassium 2-methylbutan-2-olate; sodium carbonate; sodium hydroxide; dibenzoyl peroxide;
In
ethanol; toluene; acetonitrile;
2: Fries rearrangement / 4: Suzuki coupling;
DOI:10.1021/op200299p
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium 2-methylbutan-2-olate / 100 °C
2: palladium diacetate; sodium carbonate
3: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 2 h / 78 - 82 °C / Large scale reaction
4: sodium azide / ethanol / 3 h / 60 °C / Large scale reaction
With
N-Bromosuccinimide; sodium azide; palladium diacetate; potassium 2-methylbutan-2-olate; sodium carbonate; dibenzoyl peroxide;
In
ethanol; acetonitrile;
2: Suzuki coupling;
DOI:10.1021/op200299p
