(1S)-1-(1-{[4-(3-fluorophenyl)-2-oxo-2H-chromen-7-yl]-methyl}-1H-1,2,3-triazol-4-yl)-1-(trifluoromethyl)propyl 4-nitrobenzoate

Base Information

Chemical Name:(1S)-1-(1-{[4-(3-fluorophenyl)-2-oxo-2H-chromen-7-yl]-methyl}-1H-1,2,3-triazol-4-yl)-1-(trifluoromethyl)propyl 4-nitrobenzoate
CAS No.:1044277-09-9
Molecular Formula:C₂₉H₂₀F₄N₄O₆
Molecular Weight:596.495
Hs Code.:

Synonyms:(1S)-1-(1-{[4-(3-fluorophenyl)-2-oxo-2H-chromen-7-yl]-methyl}-1H-1,2,3-triazol-4-yl)-1-(trifluoromethyl)propyl 4-nitrobenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S)-1-(1-{[4-(3-fluorophenyl)-2-oxo-2H-chromen-7-yl]-methyl}-1H-1,2,3-triazol-4-yl)-1-(trifluoromethyl)propyl 4-nitrobenzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1S)-1-(1-{[4-(3-fluorophenyl)-2-oxo-2H-chromen-7-yl]-methyl}-1H-1,2,3-triazol-4-yl)-1-(trifluoromethyl)propyl 4-nitrobenzoate

There total 11 articles about (1S)-1-(1-{[4-(3-fluorophenyl)-2-oxo-2H-chromen-7-yl]-methyl}-1H-1,2,3-triazol-4-yl)-1-(trifluoromethyl)propyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1044277-08-8
7-(azidomethyl)-4-(3-fluorophenyl)-2H-chromen-2-one

: 1044277-04-4
(S)-1-ethyl-1-(trifluoromethyl)prop-2-yn-1-yl 4-nitrobenzoate

: 1044277-09-9
(1S)-1-(1-{[4-(3-fluorophenyl)-2-oxo-2H-chromen-7-yl]-methyl}-1H-1,2,3-triazol-4-yl)-1-(trifluoromethyl)propyl 4-nitrobenzoate

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; Product distribution / selectivity;

Reference yield:

: 108-39-4
3-methyl-phenol

: 1044277-09-9
(1S)-1-(1-{[4-(3-fluorophenyl)-2-oxo-2H-chromen-7-yl]-methyl}-1H-1,2,3-triazol-4-yl)-1-(trifluoromethyl)propyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide

2: aluminum (III) chloride / toluene / 90 °C

3: potassium 2-methylbutan-2-olate / 100 °C

4: palladium diacetate; sodium carbonate

5: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 2 h / 78 - 82 °C / Large scale reaction

6: sodium azide / ethanol / 3 h / 60 °C / Large scale reaction

7: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 30 °C / Large scale reaction

With aluminum (III) chloride; N-Bromosuccinimide; copper(l) iodide; sodium azide; palladium diacetate; potassium 2-methylbutan-2-olate; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; ethanol; toluene; acetonitrile; 2: Fries rearrangement / 4: Suzuki coupling;
DOI:10.1021/op200299p

Reference yield:

: 6921-64-8
4'-hydroxy-2'-methylacetophenone

: 1044277-09-9
(1S)-1-(1-{[4-(3-fluorophenyl)-2-oxo-2H-chromen-7-yl]-methyl}-1H-1,2,3-triazol-4-yl)-1-(trifluoromethyl)propyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium 2-methylbutan-2-olate / 100 °C

2: palladium diacetate; sodium carbonate

3: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 2 h / 78 - 82 °C / Large scale reaction

4: sodium azide / ethanol / 3 h / 60 °C / Large scale reaction

5: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 30 °C / Large scale reaction

With N-Bromosuccinimide; copper(l) iodide; sodium azide; palladium diacetate; potassium 2-methylbutan-2-olate; sodium carbonate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; ethanol; acetonitrile; 2: Suzuki coupling;
DOI:10.1021/op200299p