5-(4-chlorophenyl)-4-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

Base Information

Chemical Name:5-(4-chlorophenyl)-4-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid
CAS No.:1291068-15-9
Molecular Formula:C₁₈H₁₂ClF₃N₂O₂
Molecular Weight:380.754
Hs Code.:

Synonyms:5-(4-chlorophenyl)-4-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

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Chemical Property of 5-(4-chlorophenyl)-4-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

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Technology Process of 5-(4-chlorophenyl)-4-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

There total 8 articles about 5-(4-chlorophenyl)-4-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1291068-13-7
C₂₀H₁₆ClF₃N₂O₂

: 1291068-15-9
5-(4-chlorophenyl)-4-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

Guidance literature:: With water; potassium hydroxide; In ethanol; for 3h; Reflux;
DOI:10.3109/14756366.2010.491794

Reference yield:

: 6285-05-8
4'-chloropropiophenone

: 1291068-15-9
5-(4-chlorophenyl)-4-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium iodide / acetonitrile / 5 h / 20 °C / Inert atmosphere

2: tert-butyl methyl ether / 5 h / 20 °C

3: 5 h / 20 °C

4: triethylamine / ethanol / 20 h / 20 °C

5: acetic acid / 24 h / Reflux

6: water; potassium hydroxide / ethanol / 3 h / Reflux

With water; acetic acid; triethylamine; sodium iodide; potassium hydroxide; In ethanol; tert-butyl methyl ether; acetonitrile;
DOI:10.3109/14756366.2010.491794

Reference yield:

: 1291068-11-5
C₂₀H₁₈ClF₃N₂O₃

: 1291068-15-9
5-(4-chlorophenyl)-4-methyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 24 h / Reflux

2: water; potassium hydroxide / ethanol / 3 h / Reflux

With water; acetic acid; potassium hydroxide; In ethanol;
DOI:10.3109/14756366.2010.491794