(S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate

Base Information

Chemical Name:(S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate
CAS No.:1334513-09-5
Molecular Formula:C₂₅H₃₃N₆O₈P
Molecular Weight:576.546
Hs Code.:

(S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate

Synonyms:(S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate

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Technology Process of (S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate

There total 14 articles about (S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1334513-02-8,1627824-09-2
(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

: 362-75-4
2',3'-isopropylidene adenosine

: 1334513-09-5
(S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate

Guidance literature:: 2',3'-isopropylidene adenosine; With tert-butylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 0.55h;

(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester; In tetrahydrofuran; at 20 ℃; for 18.05h;
DOI:10.1021/jo201492m

Reference yield:

: 1334513-04-0
(S)-2-[(S)-(2-chloro-4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

: 362-75-4
2',3'-isopropylidene adenosine

: 1334513-09-5
(S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate

Guidance literature:: 2',3'-isopropylidene adenosine; With tert-butylmagnesium chloride; In tetrahydrofuran; at 25 ℃; for 0.55h;

(S)-2-[(S)-(2-chloro-4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester; In tetrahydrofuran; at 25 ℃;
DOI:10.1021/jo201492m

Reference yield:

: 1334513-07-3
(2S)-isopropyl 2-(((2-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate

: 362-75-4
2',3'-isopropylidene adenosine

: 1334513-09-5
(S)-isopropyl 2-(((S)-(((3aR,4R,6R,6aR)-6-(6-amino-0H-purin-9-yl)-2,2-dimethyltetrahydrofuro-[3,4-d]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)amino)propionoate

Guidance literature:: 2',3'-isopropylidene adenosine; With tert-butylmagnesium chloride; In tetrahydrofuran; at 25 ℃; for 0.55h;

(2S)-isopropyl 2-(((2-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate; In tetrahydrofuran; at 25 ℃;
DOI:10.1021/jo201492m