N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Base Information

Chemical Name:N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide
CAS No.:1240517-61-6
Molecular Formula:C₂₄H₂₄ClFN₄O₅S₂
Molecular Weight:567.062
Hs Code.:

Synonyms:N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

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Chemical Property of N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

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Technology Process of N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

There total 8 articles about N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1240518-46-0
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

: 40635-66-3
2-acetoxy-2-methylpropanoyl chloride

: 1240517-61-6
N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Guidance literature:: N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide; 2-acetoxy-2-methylpropanoyl chloride; With pyridine; In dichloromethane; for 5h; Inert atmosphere;

With potassium carbonate; In methanol; at 40 ℃; for 1h;
DOI:10.1021/jm301572h

Reference yield:

: C₂₆H₂₆ClFN₄O₆S₂

: 1240517-61-6
N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Guidance literature:: With methanol; potassium carbonate; at 40 ℃; for 1h;

Reference yield:

: 93343-10-3
3,5-difluoroanisol

: 1240517-61-6
N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium chloride / dichloromethane / 0.25 h

2.1: hydroxylamine-O-sulfonic acid / water / 3 h / 110 °C

3.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C

4.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h

4.2: 1 h

5.1: pyridine / chloroform / 5 h / 20 °C

6.1: lithium aluminium tetrahydride; ammonia / methanol; diethyl ether; tetrahydrofuran; water / 3 h / Inert atmosphere

7.1: pyridine / dichloromethane / 5 h / Inert atmosphere

7.2: 1 h / 40 °C

With pyridine; lithium aluminium tetrahydride; ammonia; titanium chloride; hydrazine hydrate; potassium hydroxide; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm301572h