N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Base Information

Chemical Name:N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide
CAS No.:1240518-46-0
Molecular Formula:C₂₀H₁₈ClFN₄O₃S₂
Molecular Weight:480.971
Hs Code.:

Synonyms:N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

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Chemical Property of N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

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Technology Process of N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

There total 7 articles about N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1240518-47-1
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate

: 1240518-46-0
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Guidance literature:: With ammonia; In methanol; water;

Reference yield:

: 608515-57-7
2,4-difluoro-6-methoxybenzaldehyde

: 1240518-46-0
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine-O-sulfonic acid / water / 3 h / 110 °C

2.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h

3.2: 1 h

4.1: pyridine / chloroform / 5 h / 20 °C

5.1: lithium aluminium tetrahydride; ammonia / methanol; diethyl ether; tetrahydrofuran; water / 3 h / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; ammonia; hydrazine hydrate; potassium hydroxide; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; chloroform; water; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm301572h

Reference yield:

: 93343-10-3
3,5-difluoroanisol

: 1240518-46-0
N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: titanium chloride / dichloromethane / 0.25 h

2.1: hydroxylamine-O-sulfonic acid / water / 3 h / 110 °C

3.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C

4.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h

4.2: 1 h

5.1: pyridine / chloroform / 5 h / 20 °C

6.1: lithium aluminium tetrahydride; ammonia / methanol; diethyl ether; tetrahydrofuran; water / 3 h / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; ammonia; titanium chloride; hydrazine hydrate; potassium hydroxide; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm301572h