4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine

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Chemical Name:4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine
CAS No.:1421373-06-9
Molecular Formula:C₂₆H₂₈N₆O
Molecular Weight:440.548
Hs Code.:

Synonyms:4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine

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Chemical Property of 4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine

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Technology Process of 4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine

There total 8 articles about 4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 454482-11-2
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl )-1,2,3,6-tetrahydropyridine

: 1421373-07-0
4-bromo-6-methoxy-N-[4-(1-methylindol-3-yl)pyrimidin-2-yl]-benzene-1,3-diamine

: 1421373-06-9
4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; water; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1421371-97-2
4-bromo-2-methoxy-5-nitrobenzenamine

: 1421373-06-9
4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 18 h / Inert atmosphere; Reflux

2: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / water; 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; iron; ammonium chloride; toluene-4-sulfonic acid; In 1,4-dioxane; ethanol; water;

Reference yield:

: 945016-63-7
3-(2-chloro-pyrimidin-4-yl)-1H-indole

: 1421373-06-9
4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 3 h / 0 °C

2.1: toluene-4-sulfonic acid / 18 h / Inert atmosphere; Reflux

3.1: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / water; 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; iron; sodium hydride; ammonium chloride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; water; mineral oil;