1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester

Base Information

• Chemical Name: 1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester
• CAS No.: 454482-11-2
• Molecular Formula: C12H22BNO2
• Molecular Weight: 223.123
• Hs Code.: 2934999090
• Mol file: 454482-11-2.mol

Synonyms:1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE-4-BORONIC ACID PINACOL ESTER;4,4,5,5-tetramethyl-2-(1-methyl-3,5-dihydro-2H-pyrid-4-yl)-1,3,2-dioxaborolane;1-Methyl-1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine;1-Methyl-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)piperidine;Pyridine, 1,2,3,6-tetrahydro-1-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-Methyl-1,2,3,6-tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester 97%

Chemical Property of 1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester

Chemical Property:

• Vapor Pressure: 0.0151mmHg at 25°C
• Refractive Index: 1.467
• Boiling Point: 252.5 °C at 760 mmHg
• PKA: 9.25±0.40(Predicted)
• Flash Point: 106.5 °C
• PSA: 21.70000
• Density: 0.97g/cm³
• LogP: 1.81760
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: 1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester can be used as a substrate in the study of para-alkenylation reactions of toluene using thianthrene S-oxide and palladium catalyst.

Technology Process of 1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester

There total 9 articles about 1-Methyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1195-66-0) + N-methyl-4-bromo-1,2,5,6-tetrahydropyridine → 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl )-1,2,3,6-tetrahydropyridine (454482-11-2)

Guidance literature:

N-methyl-4-bromo-1,2,5,6-tetrahydropyridine; With TurboGrignard; In tetrahydrofuran; at -15 - -10 ℃; Inert atmosphere;

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at 20 ℃;

Reference yield:

bis(pinacol)diborane (73183-34-3) + 1-methyl-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine (180692-27-7) → 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl )-1,2,3,6-tetrahydropyridine (454482-11-2)

Guidance literature:

With potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 80 ℃; for 15h;

Reference yield:

C12H19BNO2(1+)*Br(1-) → 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl )-1,2,3,6-tetrahydropyridine (454482-11-2)

Guidance literature:

With sodium tetrahydroborate; In acetonitrile; at -10 - 20 ℃;

upstream raw materials:

bis(pinacol)diborane

1-methyl-4-[(trifluoromethanesulfonyl)oxy]-1,2,3,6-tetrahydropyridine

1-Methyl-4-piperidone

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

5-(1-methylpiperidin-4-yl)-3-{1-[4-(morpholin-4-ylcarbonyl)phenyl]-1H-1,2,3-triazol-4-yl}-1H-indazole

4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl}benzene-1,3-diamine

4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{4-(1-methylindol-3-yl)pyrimidine-2-yl}benzene-1,3-diamine

C₂₇H₂₇N₇O₂