5'-O-levulinyl-2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine 3'-O-(2,2,2-trichloroethyl 2-chlorophenyl phosphate)

Base Information

Chemical Name:5'-O-levulinyl-2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine 3'-O-(2,2,2-trichloroethyl 2-chlorophenyl phosphate)
CAS No.:79838-13-4
Molecular Formula:C₃₆H₃₈Cl₄N₅O₁₃P
Molecular Weight:921.509
Hs Code.:

Synonyms:5'-O-levulinyl-2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine 3'-O-(2,2,2-trichloroethyl 2-chlorophenyl phosphate)

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Chemical Property of 5'-O-levulinyl-2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine 3'-O-(2,2,2-trichloroethyl 2-chlorophenyl phosphate)

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Technology Process of 5'-O-levulinyl-2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine 3'-O-(2,2,2-trichloroethyl 2-chlorophenyl phosphate)

There total 5 articles about 5'-O-levulinyl-2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine 3'-O-(2,2,2-trichloroethyl 2-chlorophenyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 123-76-2
levulinic acid

: 79838-12-3
2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine 3'-O-(2,2,2-trichloroethyl 2-chlorophenyl phosphate)

: 79838-13-4
5'-O-levulinyl-2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine 3'-O-(2,2,2-trichloroethyl 2-chlorophenyl phosphate)

Guidance literature:: With 2,6-dimethylpyridine; 1,2-dimethyl-1H-imidazole; dicyclohexyl-carbodiimide; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 59819-52-2
2,2,2-trichloroethyl 2-chlorophenyl phosphorochloridate

: 79838-13-4
5'-O-levulinyl-2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine 3'-O-(2,2,2-trichloroethyl 2-chlorophenyl phosphate)

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / 1-methylimidazole / acetonitrile

2: 82 percent / K₂CO₃ / dioxane; methanol / 0.07 h / 20 °C

3: 82 percent / dicyclohexylcarbodiimide, 1,2-dimethylimidazole, 2,6-lutidine / dioxane / 2 h / 20 °C

With 1-methyl-1H-imidazole; 2,6-dimethylpyridine; 1,2-dimethyl-1H-imidazole; potassium carbonate; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol; acetonitrile;

Reference yield:

: 60943-92-2
2'-O-(4-methoxytetrahydropyran-4-yl)-N²-benzoylguanosine

: 79838-13-4
5'-O-levulinyl-2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine 3'-O-(2,2,2-trichloroethyl 2-chlorophenyl phosphate)

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / 2,6-lutidine / acetonitrile / 16 h / 0 °C

2: 63 percent / 1-methylimidazole / acetonitrile

3: 82 percent / K₂CO₃ / dioxane; methanol / 0.07 h / 20 °C

4: 82 percent / dicyclohexylcarbodiimide, 1,2-dimethylimidazole, 2,6-lutidine / dioxane / 2 h / 20 °C

With 1-methyl-1H-imidazole; 2,6-dimethylpyridine; 1,2-dimethyl-1H-imidazole; potassium carbonate; dicyclohexyl-carbodiimide; In 1,4-dioxane; methanol; acetonitrile;