N'-[(4-Methoxyphenyl)methylidene]-4-methylbenzene-1-sulfonohydrazide

Base Information

• Chemical Name: N'-[(4-Methoxyphenyl)methylidene]-4-methylbenzene-1-sulfonohydrazide
• CAS No.: 19350-72-2
• Molecular Formula: C15H16N2O3S
• Molecular Weight: 304.37
• DSSTox Substance ID: DTXSID50941030
• Mol file: 19350-72-2.mol

Synonyms:SCHEMBL6641811;DTXSID50941030;HMS2858A18;N'-[(4-Methoxyphenyl)methylidene]-4-methylbenzene-1-sulfonohydrazide

Chemical Property of N'-[(4-Methoxyphenyl)methylidene]-4-methylbenzene-1-sulfonohydrazide

Chemical Property:

• Boiling Point: 463°Cat760mmHg
• Flash Point: 233.8°C
• Density: 1.2g/cm³
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 304.08816355
• Heavy Atom Count: 21
• Complexity: 428

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NN=CC2=CC=C(C=C2)OC

Technology Process of N'-[(4-Methoxyphenyl)methylidene]-4-methylbenzene-1-sulfonohydrazide

There total 4 articles about N'-[(4-Methoxyphenyl)methylidene]-4-methylbenzene-1-sulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-methoxy-benzaldehyde (123-11-5) + toluene-4-sulfonic acid hydrazide (1576-35-8) → N'-(4-methoxybenzylidene)-4-methylbenzenesulfonohydrazide (19350-72-2)

Guidance literature:

In neat (no solvent); at 20 ℃; for 0.0166667h;

DOI:10.1002/open.201800206

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N'-(4-methoxybenzylidene)-4-methylbenzenesulfonohydrazide (19350-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate

2: ethanol / Heating

With hydrazine hydrate; In ethanol;

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N'-(4-methoxybenzylidene)-4-methylbenzenesulfonohydrazide (19350-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / water; tetrahydrofuran / 0.5 h / 0 °C

2: methanol / Reflux

With hydrazine hydrate; In tetrahydrofuran; methanol; water;

DOI:10.1039/c5cc07833d

upstream raw materials:

4-methoxy-benzaldehyde

toluene-4-sulfonic acid hydrazide

p-toluenesulfonyl chloride

Downstream raw materials:

(2-(4-methoxyphenyl)cyclopropane-1,1-diyl)dibenzene

Anisoylchloridtosylhydrazon

p-methylanizole

3-(4-methoxybenzylidene)-2,4-pentanedione