Technology Process of (R)-2-(4-bromophenyl)-2-cyclopropyl-N′-hydroxypropanimidamide
There total 11 articles about (R)-2-(4-bromophenyl)-2-cyclopropyl-N′-hydroxypropanimidamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine;
In
ethanol; water;
at 80 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/jm501185j
- Guidance literature:
-
With
ammonium hydroxide;
at 0 - 20 ℃;
for 3.5h;
Inert atmosphere;
DOI:10.1021/jo502550h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / tert-butyl methyl ether / -15 - 10 °C / Inert atmosphere; Large scale
2.1: lithium diisopropyl amide / tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene / -45 - 40 °C / Inert atmosphere; Large scale
2.2: -45 - 20 °C / Inert atmosphere; Large scale
2.3: 0 - 25 °C / Inert atmosphere; Large scale
3.1: hydroxylamine / water; ethanol / 2 h / 0 - 30 °C / Large scale
4.1: hydrogenchloride; N-chloro-succinimide / water; acetonitrile / 10 - 25 °C / Large scale
5.1: ammonium hydroxide / water; acetonitrile / 15 h / 5 - 20 °C / Large scale
With
hydrogenchloride; ammonium hydroxide; N-chloro-succinimide; hydroxylamine; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; n-heptane; tert-butyl methyl ether; ethylbenzene; water; acetonitrile;
