2-[4-(3-{(R)-1-[4-(5-amino-pyrazin-2-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide

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Chemical Name:2-[4-(3-{(R)-1-[4-(5-amino-pyrazin-2-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide
CAS No.:1360550-64-6
Molecular Formula:C₂₄H₂₆N₈O₂
Molecular Weight:458.523
Hs Code.:

Synonyms:2-[4-(3-{(R)-1-[4-(5-amino-pyrazin-2-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide

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Chemical Property of 2-[4-(3-{(R)-1-[4-(5-amino-pyrazin-2-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide

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Technology Process of 2-[4-(3-{(R)-1-[4-(5-amino-pyrazin-2-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide

There total 8 articles about 2-[4-(3-{(R)-1-[4-(5-amino-pyrazin-2-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 59489-71-3
5-amino-2-bromopyrazine

: 1360552-43-7
2-[4-(3-{(R)-1-cyclopropyl-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]ethyl}-[1,2,4]oxadiazol-5-yl)pyrazol-1-yl]-N,N-dimethylacetamide

: 1360550-64-6
2-[4-(3-{(R)-1-[4-(5-amino-pyrazin-2-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation; Sealed tube;
DOI:10.1021/jm501185j

Reference yield:

: 59489-71-3
5-amino-2-bromopyrazine

: 1360552-37-9
2-(4-{3-[(R)-1-(4-bromophenyl)-1-cyclopropylethyl]-[1,2,4]oxadiazol-5-yl}pyrazol-1-yl)-N,N-dimethylacetamide

: 1360550-64-6
2-[4-(3-{(R)-1-[4-(5-amino-pyrazin-2-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1360551-95-6
(R)-2-(4-bromophenyl)-2-cyclopropyl-N′-hydroxypropanimidamide

: 1360550-64-6
2-[4-(3-{(R)-1-[4-(5-amino-pyrazin-2-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.5 h / 50 °C / Inert atmosphere

1.2: 16 h / 100 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere; Sealed tube

4.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / N,N-dimethyl-formamide / 0.33 h / 90 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; potassium carbonate; 1,1'-carbonyldiimidazole; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; 3.1: |Suzuki-Miyaura Coupling / 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm501185j