4-iodo-N-{(3S)-1-[(1S)-1-methyl-2-(4-morpholinyl)-2-oxoethyl]-2-oxo-3-pyrrolidinyl}benzenesulfonamide

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Chemical Name:4-iodo-N-{(3S)-1-[(1S)-1-methyl-2-(4-morpholinyl)-2-oxoethyl]-2-oxo-3-pyrrolidinyl}benzenesulfonamide
CAS No.:935458-09-6
Molecular Formula:C₁₇H₂₂IN₃O₅S
Molecular Weight:507.349
Hs Code.:

Synonyms:4-iodo-N-{(3S)-1-[(1S)-1-methyl-2-(4-morpholinyl)-2-oxoethyl]-2-oxo-3-pyrrolidinyl}benzenesulfonamide

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Chemical Property of 4-iodo-N-{(3S)-1-[(1S)-1-methyl-2-(4-morpholinyl)-2-oxoethyl]-2-oxo-3-pyrrolidinyl}benzenesulfonamide

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Technology Process of 4-iodo-N-{(3S)-1-[(1S)-1-methyl-2-(4-morpholinyl)-2-oxoethyl]-2-oxo-3-pyrrolidinyl}benzenesulfonamide

There total 5 articles about 4-iodo-N-{(3S)-1-[(1S)-1-methyl-2-(4-morpholinyl)-2-oxoethyl]-2-oxo-3-pyrrolidinyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 478646-39-8
(3S)-3-amino-1-[(1S)-1-methyl-2-(morpholin-4-yl)-2-oxoethyl]pyrrolidin-2-one

: 98-61-3
p-Iodobenzenesulfonyl chloride

: 935458-09-6
4-iodo-N-{(3S)-1-[(1S)-1-methyl-2-(4-morpholinyl)-2-oxoethyl]-2-oxo-3-pyrrolidinyl}benzenesulfonamide

Guidance literature:: With pyridine; In acetonitrile; at 20 ℃;
DOI:10.1021/jm060870c

Reference yield:

: 478647-39-1
tert-butyl (2S)-2-((3S)-3-{[(benzyloxy)carbonyl]amino}-2-oxopyrrolidin-1-yl)propanoate

: 935458-09-6
4-iodo-N-{(3S)-1-[(1S)-1-methyl-2-(4-morpholinyl)-2-oxoethyl]-2-oxo-3-pyrrolidinyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 99.9 percent / TFA / CH₂Cl₂ / 4 h / 20 °C

2: 63 percent / O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄; N,N-diisopropylethylamine / dimethylformamide / 2.5 h

3: 96 percent / H₂ / Pd/C / ethanol / 16 h / atmospheric pressure

4: 71 percent / pyridine / acetonitrile / 20 °C

With pyridine; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm060870c

Reference yield:

: 478647-31-3
tert-butyl N-[(benzyloxy)carbonyl]-L-methionyl-L-alaninate

: 935458-09-6
4-iodo-N-{(3S)-1-[(1S)-1-methyl-2-(4-morpholinyl)-2-oxoethyl]-2-oxo-3-pyrrolidinyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: MeI / acetone / 72 h / 20 °C

1.2: 28 percent / Dowex resin (hydroxide form) / acetonitrile / 18 h / 20 °C

2.1: 99.9 percent / TFA / CH₂Cl₂ / 4 h / 20 °C

3.1: 63 percent / O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄; N,N-diisopropylethylamine / dimethylformamide / 2.5 h

4.1: 96 percent / H₂ / Pd/C / ethanol / 16 h / atmospheric pressure

5.1: 71 percent / pyridine / acetonitrile / 20 °C

With pyridine; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; methyl iodide; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm060870c