(Z)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate

Base Information

Chemical Name:(Z)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate
CAS No.:1296665-04-7
Molecular Formula:C₂₁H₂₉NO₇
Molecular Weight:407.464
Hs Code.:

Synonyms:(Z)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate

Chemical Property:

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Technology Process of (Z)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate

There total 7 articles about (Z)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₅NO₄

: 4755-77-5
Ethyl oxalyl chloride

: 1296665-04-7
(Z)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate

: (E)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c0ob00978d

Reference yield:

: tert-butyl 2-ethyl-4-(4-methoxyphenoxy)-3-oxobutanoate

: 1296665-04-7
(Z)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate

: (E)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate; ammonia / ethanol / 60 °C / Pressure tube

2: pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With pyridine; ammonium acetate; ammonia; In ethanol; dichloromethane;
DOI:10.1039/c0ob00978d

Reference yield:

: C₁₅H₁₆O₇

: 1296665-04-7
(Z)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate

: (E)-tert-butyl 3-(2-ethoxy-2-oxoacetamido)-2-ethyl-4-(4-methoxyphenoxy)but-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; water / 20 °C / Inert atmosphere

2.1: toluene / 1 h / 85 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; toluene; mineral oil / 0.75 h / Inert atmosphere

3.2: 3 h / 100 °C / Inert atmosphere

4.1: ammonium acetate; ammonia / ethanol / 60 °C / Pressure tube

5.1: pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; ammonium acetate; ammonia; water; sodium hydride; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c0ob00978d