ethyl 3-butyl-5-ethyl-6-((4-methoxyphenoxy)methyl)-3H-pyrimidin-4-one-2-carboxylate

Base Information

Chemical Name:ethyl 3-butyl-5-ethyl-6-((4-methoxyphenoxy)methyl)-3H-pyrimidin-4-one-2-carboxylate
CAS No.:1296665-16-1
Molecular Formula:C₂₁H₂₈N₂O₅
Molecular Weight:388.464
Hs Code.:

Synonyms:ethyl 3-butyl-5-ethyl-6-((4-methoxyphenoxy)methyl)-3H-pyrimidin-4-one-2-carboxylate

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Chemical Property of ethyl 3-butyl-5-ethyl-6-((4-methoxyphenoxy)methyl)-3H-pyrimidin-4-one-2-carboxylate

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Technology Process of ethyl 3-butyl-5-ethyl-6-((4-methoxyphenoxy)methyl)-3H-pyrimidin-4-one-2-carboxylate

There total 9 articles about ethyl 3-butyl-5-ethyl-6-((4-methoxyphenoxy)methyl)-3H-pyrimidin-4-one-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1296665-07-0
ethyl 4-((4-methoxyphenoxy)methyl)-5-ethyl-6-oxo-6H-1,3-oxazine-2-carboxylate

: 109-73-9,85404-21-3
N-butylamine

: 1296665-16-1
ethyl 3-butyl-5-ethyl-6-((4-methoxyphenoxy)methyl)-3H-pyrimidin-4-one-2-carboxylate

Guidance literature:: In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1039/c0ob00978d

Reference yield:

: 1296664-96-4
tert-butyl 4-(4-methoxyphenoxy)-3-oxobutanoate

: 1296665-16-1
ethyl 3-butyl-5-ethyl-6-((4-methoxyphenoxy)methyl)-3H-pyrimidin-4-one-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; toluene; mineral oil / 0.75 h / Inert atmosphere

1.2: 3 h / 100 °C / Inert atmosphere

2.1: ammonium acetate; ammonia / ethanol / 60 °C / Pressure tube

3.1: pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4.1: tetrachloromethane; triethylamine; triphenylphosphine / dichloromethane / Inert atmosphere; Reflux

5.1: tetrahydrofuran / 20 °C / Inert atmosphere

With pyridine; tetrachloromethane; ammonium acetate; ammonia; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c0ob00978d

Reference yield:

: 1267674-39-4
C₁₂H₁₂N₂O₃

: 1296665-16-1
ethyl 3-butyl-5-ethyl-6-((4-methoxyphenoxy)methyl)-3H-pyrimidin-4-one-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; water / 20 °C / Inert atmosphere

3.1: toluene / 1 h / 85 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; toluene; mineral oil / 0.75 h / Inert atmosphere

4.2: 3 h / 100 °C / Inert atmosphere

5.1: ammonium acetate; ammonia / ethanol / 60 °C / Pressure tube

6.1: pyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

7.1: tetrachloromethane; triethylamine; triphenylphosphine / dichloromethane / Inert atmosphere; Reflux

8.1: tetrahydrofuran / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; tetrachloromethane; dmap; ammonium acetate; ammonia; water; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c0ob00978d