2-[2-(4-Methoxyphenyl)-2-oxoethoxy]benzonitrile

Base Information

Chemical Name:2-[2-(4-Methoxyphenyl)-2-oxoethoxy]benzonitrile
CAS No.:301538-60-3
Molecular Formula:C₁₆H₁₃NO₃
Molecular Weight:267.284
Hs Code.:
DSSTox Substance ID:DTXSID701325569
ChEMBL ID:CHEMBL1546231

Synonyms:2-[2-(4-methoxyphenyl)-2-oxoethoxy]benzonitrile;MLS000768951;CHEMBL1546231;DTXSID701325569;HMS2795A21;STL337049;AKOS003826861;301538-60-3;SMR000433644;2-[2-(4-Methoxy-phenyl)-2-oxo-ethoxy]-benzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[2-(4-Methoxyphenyl)-2-oxoethoxy]benzonitrile

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:267.08954328
Heavy Atom Count:20
Complexity:365

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(=O)COC2=CC=CC=C2C#N

Technology Process of 2-[2-(4-Methoxyphenyl)-2-oxoethoxy]benzonitrile

There total 1 articles about 2-[2-(4-Methoxyphenyl)-2-oxoethoxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 611-20-1
salicylonitrile

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 301538-60-3
2-[2-(4-Methoxyphenyl)-2-oxoethoxy]benzonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1135/cccc20001093

Reference yield: 33.0%

: 301538-60-3
2-[2-(4-Methoxyphenyl)-2-oxoethoxy]benzonitrile

: 223788-34-9
2-(4-Methoxybenzoyl)-1-benzofuran-3-amine

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 1h;
DOI:10.1135/cccc20001093

Reference yield:

: 301538-60-3
2-[2-(4-Methoxyphenyl)-2-oxoethoxy]benzonitrile

: 301538-52-3
2-(4-Hydroxybenzoyl)-1-benzofuran-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 33 percent / CH₃ONa / methanol / 1 h / 20 °C

2: 87 percent / BBr₃ / CH₂Cl₂ / 7 h / 20 °C

With sodium methylate; boron tribromide; In methanol; dichloromethane; 1: Cyclization / 2: Ether cleavage; Demethylation;
DOI:10.1135/cccc20001093