3-amino-4-(3,5-difluoro-phenyl)-1-(3-iodo-benzylamino)-butan-2-ol

Base Information

• Chemical Name: 3-amino-4-(3,5-difluoro-phenyl)-1-(3-iodo-benzylamino)-butan-2-ol
• CAS No.: 388072-74-0
• Molecular Formula: C₁₇H₁₉F₂IN₂O
• Molecular Weight: 432.252
• Mol file: 388072-74-0.mol

Synonyms:3-amino-4-(3,5-difluoro-phenyl)-1-(3-iodo-benzylamino)-butan-2-ol

Chemical Property of 3-amino-4-(3,5-difluoro-phenyl)-1-(3-iodo-benzylamino)-butan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-4-(3,5-difluoro-phenyl)-1-(3-iodo-benzylamino)-butan-2-ol

There total 3 articles about 3-amino-4-(3,5-difluoro-phenyl)-1-(3-iodo-benzylamino)-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester (388071-41-8) → 3-amino-4-(3,5-difluoro-phenyl)-1-(3-iodo-benzylamino)-butan-2-ol (388072-74-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm061242y

Reference yield:

tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (388071-27-0) → 3-amino-4-(3,5-difluoro-phenyl)-1-(3-iodo-benzylamino)-butan-2-ol (388072-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / silica gel / CH₂Cl₂ / 72 h / 20 °C

2: TFA / CH₂Cl₂ / 1 h / 20 °C

With silica gel; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm061242y

Reference yield:

3-iodobenzylamine (696-40-2) → 3-amino-4-(3,5-difluoro-phenyl)-1-(3-iodo-benzylamino)-butan-2-ol (388072-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / silica gel / CH₂Cl₂ / 72 h / 20 °C

2: TFA / CH₂Cl₂ / 1 h / 20 °C

With silica gel; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm061242y

upstream raw materials:

(1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester

tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate

3-iodobenzylamine

Downstream raw materials:

N₁-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methyl-N₃,N₃-dipropylisophthalamide