(1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester
• CAS No.: 388071-41-8
• Molecular Formula: C₂₂H₂₇F₂IN₂O₃
• Molecular Weight: 532.369
• Mol file: 388071-41-8.mol

Synonyms:(1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester

Chemical Property of (1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester

There total 7 articles about (1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (388071-27-0) + 3-iodobenzylamine (696-40-2) → (1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester (388071-41-8)

Guidance literature:

With silica gel; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1021/jm061242y

Reference yield:

(S)-tert-butyl 3-(3,5-difluorophenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate (362480-01-1) → (1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester (388071-41-8)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrahydrofuran

2: lithium hexamethyldisilazane / tetrahydrofuran

3: N-Bromosuccinimide / tetrahydrofuran / -40 °C

4: sodium tetrahydroborate / ethanol / -78 °C

5: potassium hydroxide / ethanol

6: isopropyl alcohol / 70 °C

With sodium tetrahydroborate; N-Bromosuccinimide; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; isopropyl alcohol;

DOI:10.1002/chem.201102078

Reference yield:

C18H27F2NO3Si → (1S,2R)-[1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl]-carbamic acid tert-butyl ester (388071-41-8)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide / tetrahydrofuran / -40 °C

2: sodium tetrahydroborate / ethanol / -78 °C

3: potassium hydroxide / ethanol

4: isopropyl alcohol / 70 °C

With sodium tetrahydroborate; N-Bromosuccinimide; potassium hydroxide; In tetrahydrofuran; ethanol; isopropyl alcohol;

DOI:10.1002/chem.201102078

upstream raw materials:

tert-butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate

3-iodobenzylamine

(S)-tert-butyl 3-(3,5-difluorophenyl)-1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate

C₁₅H₁₉F₂NO₃

Downstream raw materials:

N₁-{(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl}-5-methyl-N₃,N₃-dipropylisophthalamide

3-amino-4-(3,5-difluoro-phenyl)-1-(3-iodo-benzylamino)-butan-2-ol