2-Methyl-propane-2-sulfinic acid [(S)-2-dibenzylamino-3-phenyl-prop-(E)-ylidene]-amide

Base Information

• Chemical Name: 2-Methyl-propane-2-sulfinic acid [(S)-2-dibenzylamino-3-phenyl-prop-(E)-ylidene]-amide
• CAS No.: 441045-62-1
• Molecular Formula: C₂₇H₃₂N₂OS
• Molecular Weight: 432.63

Synonyms:2-Methyl-propane-2-sulfinic acid [(S)-2-dibenzylamino-3-phenyl-prop-(E)-ylidene]-amide

Chemical Property of 2-Methyl-propane-2-sulfinic acid [(S)-2-dibenzylamino-3-phenyl-prop-(E)-ylidene]-amide

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Technology Process of 2-Methyl-propane-2-sulfinic acid [(S)-2-dibenzylamino-3-phenyl-prop-(E)-ylidene]-amide

There total 1 articles about 2-Methyl-propane-2-sulfinic acid [(S)-2-dibenzylamino-3-phenyl-prop-(E)-ylidene]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2S)-N,N-dibenzylphenylalaninal (123054-12-6,123808-74-2,136370-73-5,111060-64-1) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → 2-Methyl-propane-2-sulfinic acid [(S)-2-dibenzylamino-3-phenyl-prop-(E)-ylidene]-amide (441045-62-1)

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran; at 0 - 20 ℃; for 6h;

DOI:10.1021/ja020482+

Reference yield: 82.0%

(trifluoromethyl)trimethylsilane (81290-20-2) + 2-Methyl-propane-2-sulfinic acid [(S)-2-dibenzylamino-3-phenyl-prop-(E)-ylidene]-amide (441045-62-1) → (R)-N-((2S,3S)-3-(dibenzylamino)-1,1,1-trifluoro-4-phenylbutan-2-yl)-2-methylpropane-2-sulfinamide (441045-69-8)

Guidance literature:

With tetramethylammonium fluoride; In tetrahydrofuran; at -35 ℃; for 2h;

DOI:10.1021/ja020482+

Reference yield: 80.0%

difluoromethyl phenyl sulfone (1535-65-5) + 2-Methyl-propane-2-sulfinic acid [(S)-2-dibenzylamino-3-phenyl-prop-(E)-ylidene]-amide (441045-62-1) → C34H38F2N2O3S2 (936944-62-6)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/jo070094w

upstream raw materials:

(2S)-N,N-dibenzylphenylalaninal

(R)-2-methylpropane-2-sulfinamide

Downstream raw materials:

(R)-N-((2S,3S)-3-(dibenzylamino)-1,1,1-trifluoro-4-phenylbutan-2-yl)-2-methylpropane-2-sulfinamide

C₃₄H₃₈F₂N₂O₃S₂

N³,N³-dibenzyl-1,1,1-trifluoro-4-phenyl-butane-2,3-diamine

((1S,2S)-2-Dibenzylamino-3-phenyl-1-trifluoromethyl-propyl)-carbamic acid ethyl ester

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