(2S,4S)-2-(1-Isopropyl-4,5-dihydro-1H-imidazol-2-yl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Base Information

Chemical Name:(2S,4S)-2-(1-Isopropyl-4,5-dihydro-1H-imidazol-2-yl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester
CAS No.:708262-09-3
Molecular Formula:C₃₃H₃₇N₃O₂S
Molecular Weight:539.742
Hs Code.:

Synonyms:(2S,4S)-2-(1-Isopropyl-4,5-dihydro-1H-imidazol-2-yl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-2-(1-Isopropyl-4,5-dihydro-1H-imidazol-2-yl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,4S)-2-(1-Isopropyl-4,5-dihydro-1H-imidazol-2-yl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

There total 5 articles about (2S,4S)-2-(1-Isopropyl-4,5-dihydro-1H-imidazol-2-yl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.3%

: 75-26-3
isopropyl bromide

: 708261-99-8
(2S,4S)-2-(4,5-dihydro-1H-imidazol-2-yl)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

: 708262-09-3
(2S,4S)-2-(1-Isopropyl-4,5-dihydro-1H-imidazol-2-yl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Guidance literature:: (2S,4S)-2-(4,5-dihydro-1H-imidazol-2-yl)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine; With potassium carbonate; In acetonitrile; for 1h;

isopropyl bromide; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1002/ardp.200300756

Reference yield:

: 3695-77-0
triphenylmethanethiol

: 708262-09-3
(2S,4S)-2-(1-Isopropyl-4,5-dihydro-1H-imidazol-2-yl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 1 h / 20 °C

1.2: 82.5 percent / dimethylformamide / 3 h / 20 °C

2.1: trimethylaluminum / toluene / 1 h / 20 °C

2.2: 68.5 percent / toluene / 15 h / 50 °C

3.1: K₂CO₃ / acetonitrile / 1 h

3.2: 68.3 percent / acetonitrile / 24 h / 20 °C

With trimethylaluminum; sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/ardp.200300756

Reference yield:

: 625388-36-5
(2S,4S)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester

: 708262-09-3
(2S,4S)-2-(1-Isopropyl-4,5-dihydro-1H-imidazol-2-yl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / toluene / 1 h / 20 °C

1.2: 68.5 percent / toluene / 15 h / 50 °C

2.1: K₂CO₃ / acetonitrile / 1 h

2.2: 68.3 percent / acetonitrile / 24 h / 20 °C

With trimethylaluminum; potassium carbonate; In toluene; acetonitrile;
DOI:10.1002/ardp.200300756